AIDS and Behavior

, Volume 14, Issue 1, pp 1–10 | Cite as

Couples-Focused Behavioral Interventions for Prevention of HIV: Systematic Review of the State of Evidence

  • Jennifer Burton
  • Lynae A. Darbes
  • Don OperarioEmail author
Review Paper


HIV is frequently transmitted in the context of partners in a committed relationship, thus couples-focused HIV prevention interventions are a potentially promising modality for reducing infection. We conducted a systematic review of studies testing whether couples-focused behavioral prevention interventions reduce HIV transmission and risk behavior. We included studies using randomized controlled trial designs, quasi-randomized controlled trials, and nonrandomized controlled studies. We searched five electronic databases and screened 7,628 records. Six studies enrolling 1,084 index couples met inclusion criteria and were included in this review. Results across studies consistently indicated that couples-focused programs reduced unprotected sexual intercourse and increased condom use compared with control groups. However, studies were heterogeneous in population, type of intervention, comparison groups, and outcomes measures, and so meta-analysis to calculate pooled effects was inappropriate. Although couples-focused approaches to HIV prevention appear initially promising, additional research is necessary to build a stronger theoretical and methodological basis for couples-focused HIV prevention, and future interventions must pay closer attention to same-sex couples, adolescents, and young people in relationships.


HIV Prevention Couples Relationships Systematic review 



We would like to thank Kristen Underhill for assistance in conducting the literature review, and all researchers and primary authors who responded to our requests for additional information. This research was supported by NIDA grant R01DA018621 to Don Operario, and NIMH grant K08MH072380 to Lynae Darbes.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jennifer Burton
    • 1
  • Lynae A. Darbes
    • 2
  • Don Operario
    • 3
    Email author
  1. 1.Department of Social Policy and Social WorkUniversity of OxfordOxfordEngland
  2. 2.Center for AIDS Prevention StudiesUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of Community HealthBrown UniversityProvidenceUSA

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