AIDS and Behavior

, 13:328 | Cite as

Associations Between Substance Use, Erectile Dysfunction Medication and Recent HIV Infection Among Men Who have Sex with Men

  • Lydia N. DrumrightEmail author
  • Pamina M. Gorbach
  • Susan J. Little
  • Steffanie A. Strathdee
Original Paper


We conducted a case-control study to compare illicit substance and erectile dysfunction medication (EDM) use between recently HIV-infected and uninfected men who have sex with men (MSM). Eighty-six recently (previous 12 months) HIV-infected MSM (cases) and 59 MSM who recently tested HIV-negative (controls) completed computer-assisted self-interviews. There were no statistical differences in demographics or number of sexual partners by HIV status. Cases were more likely than controls to report methamphetamine or nitrite use, but not EDM, gamma hydroxybutyrate, 3,4 methylenedioxymethamphetamine, cocaine, or marijuana use, in the previous 12 months and with their last three sexual partners in multivariate logistic regression models. Use of nitrites and amphetamine may increase HIV risk among MSM.


HIV Primary infection Recent infection MSM Drug use Substance use Methamphetamine Volatile nitrites Sildenafil Erectile dysfunction medication 



The authors would like to acknowledge and thank Tari Gilbert, Jacqui Pitt, Paula Potter, Joanne Santangelo, and the University of California, San Diego Antiviral Research Center staff for their support in data collection; and W. Susan Cheng for her assistance in data collection and management. Most of all we would like to thank our participants for volunteering for this study. Funding for this study was provided by: the National Institutes of Allergy and Infectious Diseases, grant # AI43638 (The Southern California Primary Infections Program) and grant # 5 T32 AI07384 (AIDS Training Grant); and the Universitywide AIDS Research Program, grant # ID01-SDSU-056; grant # IS02-SD-701; grant # D03-SD-400; and grant # F06-SD-258.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Lydia N. Drumright
    • 1
    Email author
  • Pamina M. Gorbach
    • 2
  • Susan J. Little
    • 3
  • Steffanie A. Strathdee
    • 1
  1. 1.Division of International Health and Cross-Cultural Medicine, Department of Family and Preventive Medicine, School of MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.Department of Epidemiology and Division of Infectious Disease, School of MedicineUniversity of California, Los AngelesLos AngelesUSA
  3. 3.Department of Medicine, Antiviral Research CenterUniversity of California, San DiegoLa JollaUSA

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