AIDS and Behavior

, Volume 12, Issue 1, pp 95–103

Medication Adherence Mediates the Relationship between Adherence Self-efficacy and Biological Assessments of HIV Health among those with Alcohol Use Disorders

  • Jeffrey T. Parsons
  • Elana Rosof
  • Brian Mustanski
Original Paper

DOI: 10.1007/s10461-007-9241-8

Cite this article as:
Parsons, J.T., Rosof, E. & Mustanski, B. AIDS Behav (2008) 12: 95. doi:10.1007/s10461-007-9241-8


The current study examines the relationship between negative consequences of alcohol use, adherence self-efficacy, medication adherence, and biological markers of HIV health (CD4 count and viral load). A total of 275 HIV-positive men and women with alcohol use disorders were surveyed using Audio-CASI measures and time line followback interviews. Findings from a structural equation model suggest that negative consequences related to alcohol use did not directly impact HIV health. Adherence self-efficacy had direct effects on viral load, but not CD4 count. Mediation analyses indicated that self-reported adherence partially mediated the relationship between adherence self-efficacy and viral load. Cognitive-oriented interventions aimed at facilitating adherence self-efficacy may be effective in improving both medication adherence and HIV health. If facilitating confidence improves HIV health, then health care providers can make a strong impact by spending a few short minutes themselves and/or partnering with behavioral health clinicians using techniques like motivational enhancement.


Adherence Alcohol Self-efficacy Viral load CD4 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jeffrey T. Parsons
    • 1
  • Elana Rosof
    • 2
  • Brian Mustanski
    • 3
  1. 1.Department of PsychologyHunter College of the City University of New York, Center for HIV/AIDS Educational Studies and Training (CHEST)New YorkUSA
  2. 2.Center for HIV/AIDS Educational Studies and Training (CHEST), Medical and Health Research Association of NYC, IncNew YorkUSA
  3. 3.University of IllinoisChicagoUSA

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