AIDS and Behavior

, Volume 11, Issue 4, pp 603–610

The Impact of Chronic Hepatitis C on Health-Related Quality of Life in Homeless and Marginally Housed Individuals with HIV

  • Judith I. Tsui
  • David R. Bangsberg
  • Kathleen Ragland
  • Christopher S. Hall
  • Elise D. Riley
Original Paper


Although infection with Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) frequently co-exist, there has been little research to determine the effects of HIV/HCV co-infection on health-related quality of life (HRQOL). We performed a cross-sectional analysis of baseline data from 216 participants enrolled in a community based study of HIV-infected homeless and marginally housed individuals, using multivariable linear regression analysis to determine if co-infection with HCV was independently associated with lower short-form 36 (SF-36) questionnaire scores. We found that individuals with HCV had significantly lower mean SF-36 scores in the domains of physical functioning, bodily pain, social functioning and role limitation due to emotional health, and that HIV/HCV co-infection was independently associated with a lower physical component score but not a lower mental component score after controlling for numerous covariates. These results suggest that co-infection with HCV may have an adverse effect on HRQOL among homeless and marginally housed individuals with HIV.


Hepatitis C HIV Quality of Life Homelessness 



Hepatitis C virus


Health-related quality of life


Human immunodeficiency virus


Short form 36


Physical component scale


Mental component scale


Highly active anti-retroviral therapy


Homeless/marginally housed


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Judith I. Tsui
    • 1
  • David R. Bangsberg
    • 2
    • 3
  • Kathleen Ragland
    • 2
  • Christopher S. Hall
    • 3
    • 4
  • Elise D. Riley
    • 2
  1. 1.San Francisco Veterans Administration Medical CenterUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General HospitalUniversity of California San FranciscoSan FranciscoUSA
  3. 3.Positive Health ProgramSan Francisco General HospitalSan FranciscoUSA
  4. 4.STD Control Branch, California Department of Health ServicesCalifornia STD/HIV Prevention Training CenterCaliforniaUSA

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