AIDS and Behavior

, Volume 10, Issue 3, pp 227–245

Self-Report Measures of Antiretroviral Therapy Adherence: A Review with Recommendations for HIV Research and Clinical Management

  • Jane M. Simoni
  • Ann E. Kurth
  • Cynthia R. Pearson
  • David W. Pantalone
  • Joseph O. Merrill
  • Pamela A. Frick
Original Article

DOI: 10.1007/s10461-006-9078-6

Cite this article as:
Simoni, J.M., Kurth, A.E., Pearson, C.R. et al. AIDS Behav (2006) 10: 227. doi:10.1007/s10461-006-9078-6

Abstract

A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode=7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, or 44%). In 27 of 34 recall periods (79%), self-reported adherence was associated with adherence as assessed with other indirect measures. Data from 57 of 67 recall periods (84%) indicated self-reported adherence was significantly associated with HIV-1 RNA viral load; in 16 of 26 (62%), it was associated with CD4 count. Clearly, the field would benefit from item standardization and a priori definitions and operationalizations of adherence. We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.

Keywords

HIV/AIDS Antiretroviral Medication adherence Self-report Viral load 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Jane M. Simoni
    • 1
  • Ann E. Kurth
    • 2
  • Cynthia R. Pearson
    • 3
  • David W. Pantalone
    • 1
  • Joseph O. Merrill
    • 4
  • Pamela A. Frick
    • 5
  1. 1.Department of PsychologyUniversity of WashingtonSeattleUSA
  2. 2.School of Nursing/CFARUniversity of WashingtonSeattleUSA
  3. 3.School of Public Health & Community MedicineUniversity of WashingtonSeattleUSA
  4. 4.Department of MedicineUniversity of WashingtonSeattleUSA
  5. 5.Department of PharmacyUniversity of WashingtonSeattleUSA

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