Vascular co-option in brain metastasis

  • Pedro García-Gómez
  • Manuel ValienteEmail author
Review Paper


Vascular co-option by brain metastasis-initiating cells has been demonstrated as a critical step in organ colonization. The physical interaction between the cancer cell and the endothelial cell is mediated by integrins and L1CAM and could be involved in aggressive growth but also latency and immune evasion. The key involvement of vascular co-option in brain metastasis has created an emerging field that aims to identify critical targets as well as effective inhibitors with the goal of preventing brain metastases.


Brain metastasis Capillaries Breast cancer Lung cancer Melanoma Vascular co-option 



Research in the Brain Metastasis Group is supported by MINECO-Retos SAF2017-89643-R (M.V.), Bristol-Myers Squibb-Melanoma Research Alliance Young Investigator Award (498103) (M.V.), Beug Foundation’s Prize for Metastasis Research (M.V.), Fundación Ramón Areces (CIVP19S8163) (M.V.), Worldwide Cancer Research (19-0177) (M.V.), H2020-FETOPEN (828972) (M.V.), CLIP Award Cancer Research Institute (54545) (M.V.), and AECC Coordinated Translational Groups 2017 (GCTRA16015SEOA) (M.V.). P.G-G. is the recipient of La Caixa Foundation (ID100010434) and European Union´s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement (No. 713673) PhD Program Fellowship (LCF/BQ/IN17/11620028). M.V. is a Ramón y Cajal Investigator (RYC-2013-13365) and EMBO YIP (4053).


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Brain Metastasis GroupSpanish National Cancer Research Center (CNIO)MadridSpain

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