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Angiogenesis

, Volume 21, Issue 4, pp 667–675 | Cite as

Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome

  • Daniel A. P. Guerra
  • Ana E. Paiva
  • Isadora F. G. Sena
  • Patrick O. Azevedo
  • Walison N. Silva
  • Akiva Mintz
  • Alexander Birbrair
Review Paper

Abstract

Glioblastoma is the most common malignant brain cancer in adults, with poor prognosis. The blood–brain barrier limits the arrival of several promising anti-glioblastoma drugs, and restricts the design of efficient therapies. Recently, by using state-of-the-art technologies, including thymidine kinase targeting system in combination with glioblastoma xenograft mouse models, it was revealed that targeting glioblastoma-derived pericytes improves chemotherapy efficiency. Strikingly, ibrutinib treatment enhances chemotherapeutic effectiveness, by targeting pericytes, improving blood–brain barrier permeability, and prolonging survival. This study identifies glioblastoma-derived pericyte as a novel target in the brain tumor microenvironment during carcinogenesis. Here, we summarize and evaluate recent advances in the understanding of pericyte’s role in the glioblastoma microenvironment.

Keywords

Pericytes Glioblastoma Blood–brain barrier Chemotherapy 

Notes

Acknowledgements

Alexander Birbrair is supported by a grant from Instituto Serrapilheira/Serra-1708-15285, a Grant from Pró-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) (Edital 05/2016); a Grant from FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC, RED-00570-16)], and a Grant from FAPEMIG [Rede De Pesquisa Em Doenças Infecciosas Humanas E Animais Do Estado De Minas Gerais (RED-00313-16)]; Akiva Mintz is supported by the National Institute of Health (1R01CA179072-01A1) and by the American Cancer Society Mentored Research Scholar Grant (124443-MRSG-13-121-01-CDD).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Department of RadiologyColumbia University Medical CenterNew YorkUSA

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