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Angiogenesis

, Volume 17, Issue 2, pp 359–371 | Cite as

Lymphatic vessels: new targets for the treatment of inflammatory diseases

  • Lothar C. Dieterich
  • Catharina D. Seidel
  • Michael Detmar
Original Paper

Abstract

The lymphatic system plays an important role in the physiological control of the tissue fluid balance and in the initiation of immune responses. Recent studies have shown that lymphangiogenesis, the growth of new lymphatic vessels and/or the expansion of existing lymphatic vessels, is a characteristic feature of acute inflammatory reactions and of chronic inflammatory diseases. In these conditions, lymphatic vessel expansion occurs at the tissue level but also within the draining lymph nodes. Surprisingly, activation of lymphatic vessel function by delivery of vascular endothelial growth factor-C exerts anti-inflammatory effects in several models of cutaneous and joint inflammation. These effects are likely mediated by enhanced drainage of extravasated fluid and inflammatory cells, but also by lymphatic vessel-mediated modulation of immune responses. Although some of the underlying mechanisms are just beginning to be identified, lymphatic vessels have emerged as important targets for the development of new therapeutic strategies to treat inflammatory conditions. In this context, it is of great interest that some of the currently used anti-inflammatory drugs also potently activate lymphatic vessels.

Keywords

Lymphangiogenesis Inflammation Psoriasis Arthritis Endothelial cells 

Notes

Acknowledgments

We thank Alexandra Ochsenbein for providing tissue sections. Work in the authors’ laboratory is supported by the Swiss National Science Foundation, the European Research Council, the ETH Zurich, the Krebsliga Zürich and the Krebsliga Schweiz.

Conflict of interest

The authors declare no competing financial interests.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Lothar C. Dieterich
    • 1
  • Catharina D. Seidel
    • 1
  • Michael Detmar
    • 1
  1. 1.Institute of Pharmaceutical SciencesSwiss Federal Institute of Technology (ETH) ZurichZurichSwitzerland

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