, Volume 13, Issue 2, pp 149–160 | Cite as

Non-invasive imaging of angiogenesis in head and neck squamous cell carcinoma

  • Jacobus F. A. Jansen
  • Jason A. Koutcher
  • Amita Shukla-Dave


Squamous cell carcinoma of the head and neck (HNSCC) is the seventh most common cancer in the United States. Angiogenesis, the process by which new blood vessels are formed, is an essential element at the basis of both tumor growth and metastases. This review discusses pertinent aspects of the role of imaging modalities in assessing angiogenesis and anti-angiogenic therapy in advanced HNSCC.


Head and neck squamous cell carcinoma Angiogenesis Anti-angiogenic treatment Imaging techniques Magnetic resonance imaging Computed tomography Positron emission tomography Ultrasound Molecular imaging 



We thank Ms. Ada Muellner (B.A.) for editing the manuscript and Dr Diane Carlson (Dept of Pathology) for molecular pathology data on surgical specimens. The work from MSKCC reported in this review was supported by the National Cancer Institute/National Institutes of Health (grant number 1 R01 CA115895).


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Jacobus F. A. Jansen
    • 1
    • 2
  • Jason A. Koutcher
    • 1
    • 2
    • 3
  • Amita Shukla-Dave
    • 1
    • 2
  1. 1.Department of Medical PhysicsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of RadiologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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