, Volume 12, Issue 2, pp 165–175

Fibronectins in vascular morphogenesis

Review Paper


Fibronectin is an extracellular matrix protein found only in vertebrate organisms containing endothelium-lined vasculature and is required for cardiovascular development in fish and mice. Fibronectin and its splice variants containing EIIIA and EIIIB domains are highly upregulated around newly developing vasculature during embryogenesis and in pathological conditions including atherosclerosis, cardiac hypertrophy, and tumorigenesis. However, their molecular roles in these processes are not entirely understood. We review genetic studies examining functions of fibronectin and its splice variants during embryonic cardiovascular development, and discuss potential roles of fibronectin in vascular disease and tumor angiogenesis.


Alternative splicing Angiogenesis Cardiovascular development Endothelium Integrins Pericyte Vascular smooth muscle 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Greenberg Division of Cardiology, Department of Medicine, Department of Cell and Developmental BiologyWeill Medical College of Cornell UniversityNew YorkUSA
  2. 2.Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research at MITCambridgeUSA

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