, Volume 11, Issue 4, pp 311–319 | Cite as

The chick embryo chorioallantoic membrane as a model to study tumor metastasis

  • Anca Maria Cimpean
  • Domenico RibattiEmail author
  • Marius Raica
Review Paper


Tumor metastasis represents a major problem in the treatment of patients with different cancers. Specific phenotype and behavior of metastatic cells derive from specific molecular mechanisms involved in consecutive steps of the metastatic process. Several in vitro and in vivo experimental models have been utilized, but they cannot completely reproduce and characterize each step of the metastatic process. This review article is focused on the chick embryo chorioallantoic membrane as an in vivo model to study the metastatic process.


Angiogenesis Anti-angiogenesis Chorioallantoic membrane Metastasis Tumor progression 



Supported in part by MIUR (FIRB 2001), Rome, and Fondazione Cassa di Risparmio di Puglia, Bari, Italy.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Anca Maria Cimpean
    • 1
  • Domenico Ribatti
    • 2
    Email author
  • Marius Raica
    • 1
  1. 1.Department of Histology“Victor Babes” University of Medicine and Pharmacy TimisoaraTimisoaraRomania
  2. 2.Department of Human Anatomy and HistologyUniversity of Bari Medical SchoolBariItaly

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