, Volume 10, Issue 2, pp 77–88 | Cite as

Development of the retinal vasculature

  • Marcus FruttigerEmail author
Original Paper


Blood vessels that supply the inner portion of the retina are extensively reorganized during development. The vessel regression, sprouting angiogenesis, vascular remodelling and vessel differentiation events involved critically depend on cell–cell signalling between different cellular components such as neurons, glia, endothelial cells, pericytes and immune cells. Studies in mice using transgenic and gene deletion approaches have started to unravel the genetic basis of some of these signalling pathways and have lead to a much improved understanding of the molecular mechanisms controlling retinal blood vessel behaviour both during development and under pathological conditions. Such insight will provide the basis of future therapeutic approaches aimed at manipulating retinal blood vessels.


Retinal astrocytes Endothelial cells Angiogenesis Vasculogenesis Vascular remodelling Vessel regression Vaso-obliteration Hyaloid vasculature Oxygen induced retinopathy Neovascularization 



The author thanks Joanne Taylor and Christiana Ruhrberg for critical reading of the manuscript. The work was made possible by funding from the Lowy Medical Research Institute LTD and the Medical Research Council.


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Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  1. 1.UCL Institute of OphthalmologyLondonUK

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