Acta Biotheoretica

, Volume 67, Issue 2, pp 129–147 | Cite as

Multidrug Therapy for HIV Infection: Dynamics of Immune System

  • Deepmala KambojEmail author
  • M. D. Sharma
Regular Article


A mathematical model of the dynamics of the immune system is considered to illustrate the effect of its response to HIV infection, i.e. on viral growth and on T-cell dynamics. The specific immune response is measured by the levels of cytotoxic lymphocytes in a human body. The existence and stability analyses are performed for infected steady state and uninfected steady state. In order to keep infection under control, roles of drug therapies are analyzed in the presence of efficient immune response. Numerical simulations are computed and exhibited to illustrate the support of the immune system to drug therapies, so as to ensure the decay of infection and to maintain the level of healthy cells.


HIV infection CD4+ T cells Immune response Steady state Stability Efficacy 


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.MLN CollegeYamuna NagarIndia
  2. 2.Department of MathematicsKurukshetra UniversityKurukshetraIndia

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