Acta Biotheoretica

, Volume 66, Issue 3, pp 201–212 | Cite as

Importance of Initial Concentration of Factor VIII in a Mechanistic Model of In Vitro Coagulation

  • M. Susree
  • M. AnandEmail author
Regular Article


This computational study generates a hypothesis for the coagulation protein whose initial concentration greatly influences the course of coagulation. Many clinical malignancies of blood coagulation arise due to abnormal initial concentrations of coagulation factors. Sensitivity analysis of mechanistic models of blood coagulation is a convenient method to assess the effect of such abnormalities. Accordingly, the study presents sensitivity analysis, with respect to initial concentrations, of a recently developed mechanistic model of blood coagulation. Both the model and parameters to which model sensitivity is being analyzed provide newer insights into blood coagulation: the model incorporates distinct equations for plasma-phase and platelet membrane-bound species, and sensitivity to initial concentrations is a new dimension in sensitivity analysis. The results show that model predictions are most uncertain with respect to changes in initial concentration of factor VIII, and this hypothesis is supported by results from other models developed independently.


Coagulation Factor VIII Initial concentration Mechanistic model Sensitivity analysis 

Mathematics Subject Classification

49Q12 92C40 93B35 



We thank the Department of Science and Technology (DST) for financial support through Grant Number INT/RUS/RFBR/P-180.


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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemical EngineeringIndian Institute of Technology HyderabadSangareddyIndia

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