Acta Biotheoretica

, Volume 61, Issue 3, pp 291–303 | Cite as

How to Build a Multiscale Model in Biology

Original Article


Biological processes span several scales in space, from the single molecules to organisms and ecosystems. Multiscale modelling approaches in biology are useful to take into account the complex interactions between different organisation levels in those systems. We review several single- and multiscale models, from the most simple to the complex ones, and discuss their properties from a multiscale point of view. Approaches based on master equations for stochastic processes, individual-based models, hybrid continuous-discrete models and structured PDE models are presented.


Multiscale model Master equation Reaction-diffusion equation Hybrid modelling Individual-based modelling Structured PDE 


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Institut Camille Jordan, CNRS UMR 5208Université de LyonVilleurbanneFrance
  2. 2.Équipe Inria DraculaVilleurbanneFrance
  3. 3.Rhône-Alpes Complex Systems Institute (IXXI)LyonFrance

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