Acta Biotheoretica

, Volume 53, Issue 1, pp 39–47

Support Vector Machines for Predicting Apoptosis Proteins Types

Article

Abstract

Apoptosis proteins have a central role in the development and homeostasis of an organism. These proteins are very important for understanding the mechanism of programmed cell death, and their function is related to their types. According to the classification scheme by Zhou and Doctor (2003), the apoptosis proteins are categorized into the following four types: (1) cytoplasmic protein; (2) plasma membrane-bound protein; (3) mitochondrial inner and outer proteins; (4) other proteins. A powerful learning machine, the Support Vector Machine, is applied for predicting the type of a given apoptosis protein by incorporating the sqrt-amino acid composition effect. High success rates were obtained by the re-substitute test (98/98 = 100 %) and the jackknife test (89/98 = 90.8%).

Key Words

support vector machine subcellular location sqrt-amino acid composition 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.School of ComputerWuhan UniversityWuhanPR China
  2. 2.School of ScienceHuazhong Agricultural UniversityWuhanPR China
  3. 3.School of Mathematics and StatisticsWuhan UniversityWuhanPR China

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