Annals of Biomedical Engineering

, Volume 47, Issue 12, pp 2402–2415 | Cite as

Magnetic Resonance Navigation for Targeted Embolization in a Two-Level Bifurcation Phantom

  • Ning Li
  • Yuting Jiang
  • Rosalie Plantefève
  • Francois Michaud
  • Zeynab Nosrati
  • Charles Tremblay
  • Katayoun Saatchi
  • Urs O. Häfeli
  • Samuel Kadoury
  • Gerald Moran
  • Florian Joly
  • Sylvain Martel
  • Gilles SoulezEmail author


This work combines a particle injection system with our proposed magnetic resonance navigation (MRN) sequence with the intention of validating MRN in a two-bifurcation phantom for endovascular treatment of hepatocellular carcinoma (HCC). A theoretical physical model used to calculate the most appropriate size of the magnetic drug-eluting bead (MDEB, 200 μm) aggregates was proposed. The aggregates were injected into the phantom by a dedicated particle injector while a trigger signal was automatically sent to the MRI to start MRN which consists of interleaved tracking and steering sequences. When the main branch of the phantom was parallel to B0, the aggregate distribution ratio in the (left–left, left–right, right–left and right–right divisions was obtained with results of 8, 68, 24 and 0% respectively at baseline (no MRN) and increased to 84%, 100, 84 and 92% (p < 0.001, p = 0.004, p < 0.001, p < 0.001) after implementing our MRN protocol. When the main branch was perpendicular to B0, the right-left branch, having the smallest baseline distribution rate of 0%, reached 80% (p < 0.001) after applying MRN. Moreover, the success rate of MRN was always more than 92% at the 1st bifurcation in the experiments above.


Magnetic resonance navigation Two-bifurcations navigation Hepatocellular carcinoma Embolization 



Drug-eluting bead


Hepatocellular carcinoma


Magnetic resonance imaging


Magnetic resonance navigation


Magnetic drug-eluting bead


Trans-catheter arterial chemoembolization



This work was supported by a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC), Operating Grant—CHRP (CIHR Partnered) (CHRP 478474-15) and Canadian Institutes of Health Research (CIHR), Operating Grant—CHRP (NSERC Partnered) (CPG-140179).


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Copyright information

© Biomedical Engineering Society 2019

Authors and Affiliations

  • Ning Li
    • 1
    • 2
  • Yuting Jiang
    • 2
    • 3
  • Rosalie Plantefève
    • 2
  • Francois Michaud
    • 2
    • 3
  • Zeynab Nosrati
    • 4
  • Charles Tremblay
    • 1
  • Katayoun Saatchi
    • 4
  • Urs O. Häfeli
    • 4
  • Samuel Kadoury
    • 1
    • 2
  • Gerald Moran
    • 5
  • Florian Joly
    • 6
  • Sylvain Martel
    • 1
  • Gilles Soulez
    • 2
    • 3
    Email author
  1. 1.Polytechnique Montréal, Chemin de PolytechniqueMontréalCanada
  2. 2.Laboratory of Clinical Image ProcessingLe Centre de recherche du CHUM (CRCHUM)MontréalCanada
  3. 3.Department of Radiology, Radiation-Oncology and Nuclear Medicine and Institute of Biomedical Engineering, Université de MontréalMontréalCanada
  4. 4.University of British ColumbiaVancouverCanada
  5. 5.Siemens CanadaOakvilleCanada
  6. 6.INRIA ParisParisFrance

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