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Development of a Computational Method for Simulating Tricuspid Valve Dynamics

  • Shelly Singh-Gryzbon
  • Vahid Sadri
  • Milan Toma
  • Eric L. Pierce
  • Zhenglun A. Wei
  • Ajit P. YoganathanEmail author
Article
  • 45 Downloads

Abstract

Computational modeling can be used to improve understanding of tricuspid valve (TV) biomechanics and supplement knowledge gained from benchtop and large animal experiments. The aim of this study was to develop a computational model of the TV using high resolution micro-computed tomography (μCT) imaging and fluid–structure interaction simulations. A three-dimensional TV model, incorporating detailed leaflet and chordal geometries, was reconstructed from μCT images of an excised porcine TV obtained under diastolic conditions. The leaflets were described using non-linear stress–strain relations and chordal properties were iteratively adjusted until valve closure was obtained. The leaflet coaptation zone obtained from simulation of valve closure was validated against μCT images of the TV captured at peak systole. The computational model was then used to simulate a regurgitant TV morphology and investigate changes in closure dynamics. Overall, the mean stresses in the leaflet belly region and the chordae tendinae of the regurgitant TV were 7% and 3% higher than the same regions of the normal TV. The maximum principal strain in the leaflet belly of the regurgitant TV was also 9% higher than the same regions of the normal TV. It is anticipated that this computational model can be used in future studies for further understanding of TV biomechanics and associated percutaneous repairs.

Keywords

Biomechanics SPH Tricuspid regurgitation Micro-CT Fluid–structure interaction 

Abbreviations

3D

Three dimensional

AL

Anterior leaflet

APM

Anterior papillary muscle

CFD

Computational fluid dynamics

CRHS

Cylindrical right heart simulator

CT

Computed tomography

FE

Finite element

FSI

Fluid–structure interaction

PL

Posterior leaflet

PPM

Posterior papillary muscle

PM

Papillary muscle

SL

Septal leaflet

SPH

Smooth particle hydrodynamics

SPM

Septal papillary muscle

TR

Tricuspid regurgitation

TTV

Transcatheter tricuspid valve

TV

Tricuspid valve

Notes

Acknowledgments

The authors would like to acknowledge Charlie Bloodworth for his technical assistance with the in vitro methods used in this study; Shaily Shah for assisting with the model segmentation and smoothing; and Mandy Salmon for assisting with the chordal iterations.

Disclosures

The authors have no disclosures relevant to this work

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Copyright information

© Biomedical Engineering Society 2019

Authors and Affiliations

  1. 1.The Wallace H. Coulter School of Biomedical EngineeringGeorgia Institute of Technology & Emory UniversityAtlantaUSA
  2. 2.Department of Mechanical Engineering, School of Engineering & Computing SciencesNew York Institute of TechnologyNew YorkUSA

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