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Health-Related Quality of Life Following Concussion in Collegiate Student-Athletes With and Without Concussion History

  • Special Issue on the NCAA-DoD CARE Consortium Research
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Abstract

The purpose of this study was to compare global and specific health-related quality of life (HRQOL) throughout concussion recovery between those with and without concussion history. Student-athletes diagnosed with concussion completed global (Short Form-12v2; SF-12) and specific (Hospital Anxiety and Depression Scale: HADS) HRQOL assessments at baseline, 24–48 h, asymptomatic, return-to-play, and 6-months post-injury. Baseline scores were compared to post-injury time points for SF-12 subscores (physical and mental; PCS-12, MCS-12) and HADS subscores (depression and anxiety; HADS-D, HADS-A). We conducted a 2 × 5 mixed model ANOVA for group (with and without concussion history) and time (four post-injury assessments compared to baseline). We did not observe interaction or main effects for group, except those with concussion history had worse HADS-D subscores than those without concussion history. PCS-12 subscores were worse at 24–48 h, asymptomatic, and return-to-play compared to baseline, but returned to baseline 6-months post-injury. MCS-12 subscores did not differ at any time points. HADS-D subscores worsened 24–48 h post-injury, but improved for additional assessments compared to baseline. HADS-A improved post-injury compared to baseline at asymptomatic, return-to-play, and 6-month assessments, but was similar to baseline 24–48 h post-injury. HRQOL physical aspects slightly worsened post-injury and restored to baseline after returning to play.

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Acknowledgments

CARE Consortium Investigators are as follows: April Marie (Reed) Hoy, MS, ATC (Azusa Pacific University); Joseph B. Hazzard Jr, EdD, ATC (Bloomsburg University); Louise A. Kelly, PhD (California Lutheran University); Justus D. Ortega, PhD (Humboldt State University); Nicholas Port, PhD (Indiana University); Margot Putukian MD (Princeton University); T. Dianne Langford, PhD, and Ryan Tierney, PhD, ATC (Temple University); Darren E. Campbell, MD, and Gerald McGinty, DPT (United States Air Force Academy); Patrick O’Donnell, MHA (United States Coast Guard Academy); Holly J. Benjamin MD (University of Chicago); Thomas Buckley, EdD, ATC, and Thomas W. Kaminski, PhD, ATC (University of Delaware); James R. Clugston, MD, MS (University of Florida); Julianne D. Schmidt, PhD, ATC (University of Georgia); Luis A. Feigenbaum, DPT, ATC (University of Miami); James T. Eckner, MD, MS (University of Michigan); Kevin Guskiewicz, PhD, ATC, and Jason P. Mihalik, PhD, CAT(C), ATC (University of North Carolina at Chapel Hill); Jessica Dysart Miles, PhD, ATC (University of North Georgia); Christina L. Master, MD (University of Pennsylvania); Micky Collins, PhD, and Anthony P. Kontos, PhD (University of Pittsburgh Medical Center); Jeffrey J. Bazarian, MD, MPH (University of Rochester); Sara P.D. Chrisman, MD, MPH (University of Washington); Christopher Todd Bullers, MD, and Christopher M. Miles, MD (Wake Forest University); Brian H. Dykhuizen, MS, ATC (Wilmington College).

Funding

This project was supported, in part, with support from the Grand Alliance Concussion Assessment, Research, and Education (CARE) Consortium, funded, in part by the National Collegiate Athletic Association (NCAA) and the Department of Defense (DOD). The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Psychological Health and Traumatic Brain Injury Program under Award NO W81XWH-14-2-0151. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense (DHP funds).

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Authors and Affiliations

  1. Concussion Research Laboratory, Department of Kinesiology, University of Georgia, Athens, GA, USA

    M. L. Weber, R. C. Lynall, E. H. Miller & J. D. Schmidt

  2. School of Kinesiology and Recreation, Illinois State University, Normal, IL, USA

    N. L. Hoffman

  3. Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA

    T. W. Kaminski & T. A. Buckley

  4. Orthopaedic Surgery, Rehabilitation Medicine & Pediatrics, University of Chicago, Chicago, IL, USA

    H. J. Benjamin

  5. Department of Family and Community Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA

    C. M. Miles & L. Lintner

  6. Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA

    C. T. Whitlow

  7. Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA

    C. T. Whitlow

  8. NeuroTruama Research Laboratory, University of Michigan Injury Center, University of Michigan, Ann Arbor, MI, USA

    S. P. Broglio

  9. Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA

    M. McCrea

  10. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

    T. McAllister

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  1. M. L. Weber
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  2. R. C. Lynall
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Correspondence to M. L. Weber.

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Associate Editor Stefan Duma oversaw the review of this article.

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Weber, M.L., Lynall, R.C., Hoffman, N.L. et al. Health-Related Quality of Life Following Concussion in Collegiate Student-Athletes With and Without Concussion History. Ann Biomed Eng 47, 2136–2146 (2019). https://doi.org/10.1007/s10439-018-02151-7

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  • DOI: https://doi.org/10.1007/s10439-018-02151-7

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