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Annals of Biomedical Engineering

, Volume 46, Issue 12, pp 2177–2188 | Cite as

Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach

  • Arash Abiri
  • Yichen Ding
  • Parinaz Abiri
  • René R. Sevag Packard
  • Vijay Vedula
  • Alison Marsden
  • C.-C. Jay Kuo
  • Tzung K. Hsiai
Article

Abstract

While virtual reality (VR) has potential in enhancing cardiovascular diagnosis and treatment, prerequisite labor-intensive image segmentation remains an obstacle for seamlessly simulating 4-dimensional (4-D, 3-D + time) imaging data in an immersive, physiological VR environment. We applied deformable image registration (DIR) in conjunction with 3-D reconstruction and VR implementation to recapitulate developmental cardiac contractile function from light-sheet fluorescence microscopy (LSFM). This method addressed inconsistencies that would arise from independent segmentations of time-dependent data, thereby enabling the creation of a VR environment that fluently simulates cardiac morphological changes. By analyzing myocardial deformation at high spatiotemporal resolution, we interfaced quantitative computations with 4-D VR. We demonstrated that our LSFM-captured images, followed by DIR, yielded average dice similarity coefficients of 0.92 ± 0.05 (n = 510) and 0.93 ± 0.06 (n = 240) when compared to ground truth images obtained from Otsu thresholding and manual segmentation, respectively. The resulting VR environment simulates a wide-angle zoomed-in view of motion in live embryonic zebrafish hearts, in which the cardiac chambers are undergoing structural deformation throughout the cardiac cycle. Thus, this technique allows for an interactive micro-scale VR visualization of developmental cardiac morphology to enable high resolution simulation for both basic and clinical science.

Keywords

Medical simulation Light-sheet imaging Cardiology Image registration Dynamic imaging Surgical simulation 

Notes

Acknowledgments

This work was supported by the National Institutes of Health (5R01HL083015-10, 1R01HL118650, 1R01HL129727, 7R01HL111437) and the American Heart Association (Career Development Award 18CDA34110338, Scientist Development Grant 16SDG30910007).

Conflict of interest

The authors declare no competing financial interests.

Supplementary material

10439_2018_2113_MOESM1_ESM.mov (7 mb)
4-D VR Simulation of contracting embryonic zebrafish heart. Video of the 4-D VR simulation of a contracting embryonic zebrafish heart throughout an entire cardiac cycle. The VR scene was generated and visualized using the Unity engine. Supplementary material 1 (MOV 7180 kb)

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Copyright information

© Biomedical Engineering Society 2018

Authors and Affiliations

  • Arash Abiri
    • 1
    • 2
    • 4
  • Yichen Ding
    • 1
    • 2
  • Parinaz Abiri
    • 1
    • 2
  • René R. Sevag Packard
    • 2
  • Vijay Vedula
    • 5
  • Alison Marsden
    • 5
    • 6
    • 7
  • C.-C. Jay Kuo
    • 8
  • Tzung K. Hsiai
    • 1
    • 2
    • 3
  1. 1.Department of BioengineeringUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Medical EngineeringCalifornia Institute of TechnologyPasadenaUSA
  4. 4.Department of Biomedical EngineeringUniversity of CaliforniaIrvineUSA
  5. 5.Department of Pediatrics (Cardiology)Stanford UniversityStanfordUSA
  6. 6.Department of BioengineeringStanford UniversityStanfordUSA
  7. 7.Institute for Computational and Mathematical EngineeringStanford UniversityStanfordUSA
  8. 8.Department of Electrical EngineeringUniversity of Southern CaliforniaLos AngelesUSA

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