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Annals of Biomedical Engineering

, Volume 45, Issue 2, pp 508–519 | Cite as

3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions

  • Marija Vukicevic
  • Daniel S. Puperi
  • K. Jane Grande-Allen
  • Stephen H. Little
The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair

Abstract

As catheter-based structural heart interventions become increasingly complex, the ability to effectively model patient-specific valve geometry as well as the potential interaction of an implanted device within that geometry will become increasingly important. Our aim with this investigation was to combine the technologies of high-spatial resolution cardiac imaging, image processing software, and fused multi-material 3D printing, to demonstrate that patient-specific models of the mitral valve apparatus could be created to facilitate functional evaluation of novel trans-catheter mitral valve repair strategies. Clinical 3D transesophageal echocardiography and computed tomography images were acquired for three patients being evaluated for a catheter-based mitral valve repair. Target anatomies were identified, segmented and reconstructed into 3D patient-specific digital models. For each patient, the mitral valve apparatus was digitally reconstructed from a single or fused imaging data set. Using multi-material 3D printing methods, patient-specific anatomic replicas of the mitral valve were created. 3D print materials were selected based on the mechanical testing of elastomeric TangoPlus materials (Stratasys, Eden Prairie, Minnesota, USA) and were compared to freshly harvested porcine leaflet tissue. The effective bending modulus of healthy porcine MV tissue was significantly less than the bending modulus of TangoPlus (p < 0.01). All TangoPlus varieties were less stiff than the maximum tensile elastic modulus of mitral valve tissue (3697.2 ± 385.8 kPa anterior leaflet; 2582.1 ± 374.2 kPa posterior leaflet) (p < 0.01). However, the slopes of the stress-strain toe regions of the mitral valve tissues (532.8 ± 281.9 kPa anterior leaflet; 389.0 ± 156.9 kPa posterior leaflet) were not different than those of the Shore 27, Shore 35, and Shore 27 with Shore 35 blend TangoPlus material (p > 0.95). We have demonstrated that patient-specific mitral valve models can be reconstructed from multi-modality imaging datasets and fabricated using the multi-material 3D printing technology and we provide two examples to show how catheter-based repair devices could be evaluated within specific patient 3D printed valve geometry. However, we recognize that the use of 3D printed models for the development of new therapies, or for specific procedural training has yet to be defined.

Keywords

Heart valve modeling Percutaneous mitral valve repair 3D printing MitraClip 

Abbreviations

CT

Computed tomography

DICOM

Digital imaging and communication in medicine

IPS

Image processing software

LA

Left atrium

LV

Left ventricle

MR

Mitral regurgitation

MV

Mitral valve

3D TEE

Three-dimensional transesophageal Echocardiography

TMVR

Trans-catheter mitral valve replacement

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Copyright information

© Biomedical Engineering Society 2016

Authors and Affiliations

  • Marija Vukicevic
    • 1
  • Daniel S. Puperi
    • 2
  • K. Jane Grande-Allen
    • 2
  • Stephen H. Little
    • 1
  1. 1.Department of CardiologyHouston Methodist Research Institute, Weill Cornell Medicine/Houston Methodist HospitalHoustonUSA
  2. 2.Department of BioengineeringRice UniversityHoustonUSA

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