Shear Stress Metrics and Their Relation to Atherosclerosis: An In Vivo Follow-up Study in Atherosclerotic Mice
- 611 Downloads
It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stage is challenging to perform in vivo on a within-subject basis. In this study, we assessed carotid hemodynamics and derived hemodynamic wall parameters from subject-specific fluid–structure interaction simulations in the left and right carotid arteries of 4 ApoE−/− mice prior to disease development. We then applied a point-by-point quantitative association (surrogate sample data analysis) between various established and more recent shear related parameters and the extent of macrophage infiltration at a later stage. We conclude that, for the atherosclerotic murine carotid bifurcation, (i) there is an association between hemodynamics and macrophage infiltration; (ii) this correlation is most apparent when assessed at the level of the entire carotid bifurcation; (iii) the strongest spatial correlation between hemodynamics and atherosclerosis development was found for the time averaged wall shear stress (negative correlation) and the relative residence time (positive correlation); (iv) aggregating the data leads to an overestimation of the correlation.
KeywordsFluid–structure interaction Mouse models Hemodynamics Wall shear stress Atherosclerosis CT
David De Wilde is supported by a research grant of the Flemish government agency for Innovation by Science and Technology (IWT). Bram Trachet receives support from a BOF grand of Ghent University. We thank Francisco Londono, Mathias Peirlinck, Christian Vanhove, Benedicte Descamps, Scharon Bruneel, Bert Vandeghinste, Nic Debusschere, Abigail Swillens, Joris Degroote, Jan Vierendeels, Francesco Iannaccone, Liesbeth Taelman, Joris Bols and Carole Van der Donckt for their assistance.
Conflict of interest
No conflict of interest.
- 2.De Wilde D., B. Trachet, N. Debusschere, F. Iannaccone, A. Swillens, J. Degroote, J. Vierendeels, G.R.Y. De Meyer, P. Segers. Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations. J Biomech. Accepted for publication,2015.Google Scholar
- 3.De Wilde, D., B. Trachet, C. Van der Donckt, B. Vandeghinste, B. Descamps, C. Vanhove, G. R. Y. De Meyer, and P. Segers. Vulnerable plaque detection and quantification with gold particle-enhanced computed tomography in atherosclerotic mouse models. Mol. Imaging. 14:9–19, 2015.Google Scholar
- 5.Gijsen, F. J. H. H., J. J. Wentzel, A. Thury, B. Lamers, J. C. H. H. Schuurbiers, P. W. Serruys, and A. F. van der Steen. A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo. J. Biomech. 40:2349–2357, 2007.CrossRefPubMedGoogle Scholar
- 23.Van der Donckt, C., J. L. Van Herck, D. M. Schrijvers, G. Vanhoutte, M. Verhoye, I. Blockx, et al. Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death. Eur. Heart J. 36:1049–1058, 2014.CrossRefPubMedPubMedCentralGoogle Scholar