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Annals of Biomedical Engineering

, Volume 44, Issue 3, pp 750–772 | Cite as

Monitoring/Imaging and Regenerative Agents for Enhancing Tissue Engineering Characterization and Therapies

  • Daniela Y. Santiesteban
  • Kelsey Kubelick
  • Kabir S. Dhada
  • Diego Dumani
  • Laura SuggsEmail author
  • Stanislav EmelianovEmail author
Nondestructive Characterization of Biomaterials for Tissue Engineering and Drug Delivery

Abstract

The past three decades have seen numerous advances in tissue engineering and regenerative medicine (TERM) therapies. However, despite the successes there is still much to be done before TERM therapies become commonplace in clinic. One of the main obstacles is the lack of knowledge regarding complex tissue engineering processes. Imaging strategies, in conjunction with exogenous contrast agents, can aid in this endeavor by assessing in vivo therapeutic progress. The ability to uncover real-time treatment progress will help shed light on the complex tissue engineering processes and lead to development of improved, adaptive treatments. More importantly, the utilized exogenous contrast agents can double as therapeutic agents. Proper use of these Monitoring/Imaging and Regenerative Agents (MIRAs) can help increase TERM therapy successes and allow for clinical translation. While other fields have exploited similar particles for combining diagnostics and therapy, MIRA research is still in its beginning stages with much of the current research being focused on imaging or therapeutic applications, separately. Advancing MIRA research will have numerous impacts on achieving clinical translations of TERM therapies. Therefore, it is our goal to highlight current MIRA progress and suggest future research that can lead to effective TERM treatments.

Keywords

Regenerative medicine Imaging contrast agents Therapeutic agents Multimodal tracking In vivo imaging In vivo tracking Stem cells Scaffold engineering Real-time imaging 

Abbreviations

ADV

Acoustic droplet vaporization

ALP

Alkaline phosphatase

AuNC

Gold nanocage

AuNP

Gold nanoparticle

AuNR

Gold nanorod

AuNS

Gold nanosphere

BBB

Blood-brain barrier

bFGF

Basic fibroblast growth factors

CNTs

Carbon nanotubes

CT

Computed tomography

CTAB

Cetyltrimethylammonium bromide

GF

Growth factor

GNB

Gold nanobeacon

HACC

Hydroxypropyltrimethyl ammonium chloride chitosan

HEMA

(Hydroxyethyl)methacrylate

ICG

Indocyanine green

IONPs

Iron oxide nanoparticles

MB

Microbubble

MIRAs

Monitoring/Imaging and Regenerative Agents

MRI

Magnetic resonance imaging

MSC

Mesenchymal stem cell

MSN

Mesoporous silica nanoparticle

MWCNT

Multiple-wall carbon nanotube

ND

Nanodroplet

NIR

Near infrared

NO

Nitric oxide

PA

Photoacoustic

pDNA

Plasmid DNA

PEG

Polyethylene glycol

PEI

Poly(ethyleneimine)

PET

Positron emission tomography

PFC

Perfluorocarbon

PFCp

Perfluorocarbon particle

PLGA

Poly(lactide-co-glycolide)

PVA

Polyvinyl alcohol

SC

Stem cell

SiNP

Solid silica nanoparticle

SPIONs

Superparamagnetic iron oxide nanoparticles

SPR

Surface plasmon resonance

SWCNT

Single-walled carbon nanotube

TERM

Tissue engineering and regenerative medicine

US

Ultrasound

VCAM-1

Vascular cell adhesion molecule 1

VEGF

Vascular endothelial growth factor

VEGFR

Vascular endothelial growth factor receptor

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Copyright information

© Biomedical Engineering Society 2015

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringUniversity of Texas at AustinAustinUSA
  2. 2.School of Electrical and Computer Engineering, Georgia Institute of TechnologyAtlantaUSA
  3. 3.Wallace H. Coulter Department of Biomedical EngineeringGeorgia Institute of Technology, Emory University School of MedicineAtlantaUSA

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