On the Compressibility of Arterial Tissue
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Arterial tissue is commonly assumed to be incompressible. While this assumption is convenient for both experimentalists and theorists, the compressibility of arterial tissue has not been rigorously investigated. In the current study we present an experimental-computational methodology to determine the compressibility of aortic tissue and we demonstrate that specimens excised from an ovine descending aorta are significantly compressible. Specimens are stretched in the radial direction in order to fully characterise the mechanical behaviour of the tissue ground matrix. Additionally biaxial testing is performed to fully characterise the anisotropic contribution of reinforcing fibres. Due to the complexity of the experimental tests, which entail non-uniform finite deformation of a non-linear anisotropic material, it is necessary to implement an inverse finite element analysis scheme to characterise the mechanical behaviour of the arterial tissue. Results reveal that ovine aortic tissue is highly compressible; an effective Poisson’s ratio of 0.44 is determined for the ground matrix component of the tissue. It is also demonstrated that correct characterisation of material compressibility has important implications for the calibration of anisotropic fibre properties using biaxial tests. Finally it is demonstrated that correct treatment of material compressibility has significant implications for the accurate prediction of the stress state in an artery under in vivo type loading.
KeywordsCompressibility Anisotropy Hyperelasticity Arterial tissue Mechanical properties
The authors wish to acknowledge funding from Science Foundation Ireland under project SFI-12/IP/1723. Furthermore we acknowledge funding from the Irish Research Council and the College of Engineering and Informatics at NUI, Galway. The authors wish to thank Noel Reynods and Prof. Michel Destrade for insightful discussions on this topic.
- 1.Anderson, T. L. Fracture mechanics: fundamentals and applications. Boca Raton: CRC press, 2005.Google Scholar
- 9.Dobrin, P., and A. Rovick. Static elastic properties of dog carotid arterial wall. Fed. Proc. 26:439, 1967.Google Scholar
- 17.Holzapfel, G. A. Nonlinear solid mechanics: a continuum approach for engineers. Wiley: Chichester, 2000.Google Scholar
- 22.Humphrey, J. D. Cardiovascular solid mechanics: cells, tissues, and organs. Springer: New York, 2002.Google Scholar
- 29.Peña, E., A. P. Del Palomar, B. Calvo, M. Martínez, and M. Doblaré. Computational modelling of diarthrodial joints. physiological, pathological and pos-surgery simulations. Arch. Comput. Methods Eng. 14:47–91, 2007.Google Scholar
- 32.Sacks, M. S. Biaxial mechanical evaluation of planar biological materials. J. Elast. Phys. Sci. Solids 61:199–246, 2000.Google Scholar
- 34.Silver, F., D. Christiansen, and C. Buntin. Mechanical properties of the aorta: a review. Crit. Rev. Biomed. Eng. 17:323–358, 1988.Google Scholar