Annals of Biomedical Engineering

, Volume 43, Issue 10, pp 2314–2333 | Cite as

Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies

  • Arash Kheradvar
  • Elliott M. Groves
  • Ahmad Falahatpisheh
  • Mohammad K. Mofrad
  • S. Hamed Alavi
  • Robert Tranquillo
  • Lakshmi P. Dasi
  • Craig A. Simmons
  • K. Jane Grande-Allen
  • Craig J. Goergen
  • Frank Baaijens
  • Stephen H. Little
  • Suncica Canic
  • Boyce Griffith
Article

Abstract

In this final portion of an extensive review of heart valve engineering, we focus on the computational methods and experimental studies related to heart valves. The discussion begins with a thorough review of computational modeling and the governing equations of fluid and structural interaction. We then move onto multiscale and disease specific modeling. Finally, advanced methods related to in vitro testing of the heart valves are reviewed. This section of the review series is intended to illustrate application of computational methods and experimental studies and their interrelation for studying heart valves.

Keywords

Computational modeling Heart valves Particle image velocimetry Biaxial testing Multiscale modeling Numerical simulation 

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Copyright information

© Biomedical Engineering Society 2015

Authors and Affiliations

  • Arash Kheradvar
    • 1
    • 2
  • Elliott M. Groves
    • 1
    • 2
  • Ahmad Falahatpisheh
    • 1
  • Mohammad K. Mofrad
    • 3
  • S. Hamed Alavi
    • 1
  • Robert Tranquillo
    • 4
  • Lakshmi P. Dasi
    • 5
  • Craig A. Simmons
    • 6
    • 7
  • K. Jane Grande-Allen
    • 8
  • Craig J. Goergen
    • 9
  • Frank Baaijens
    • 10
  • Stephen H. Little
    • 11
  • Suncica Canic
    • 12
  • Boyce Griffith
    • 13
    • 14
  1. 1.Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular TechnologyUniversity of California, IrvineIrvineUSA
  2. 2.Department of Medicine, Division of CardiologyUniversity of California, Irvine School of MedicineIrvineUSA
  3. 3.Department of Bioengineering and Mechanical EngineeringUniversity of CaliforniaBerkeleyUSA
  4. 4.Department of Biomedical EngineeringUniversity of MinnesotaMinneapolisUSA
  5. 5.Department of Mechanical Engineering, School of Biomedical EngineeringColorado State UniversityFort CollinsUSA
  6. 6.Department of Mechanical & Industrial EngineeringUniversity of TorontoTorontoCanada
  7. 7.Institute of Biomaterials & Biomedical EngineeringUniversity of TorontoTorontoCanada
  8. 8.Department of BioengineeringRice UniversityHoustonUSA
  9. 9.Weldon School of Biomedical EngineeringPurdue UniversityWest LafayetteUSA
  10. 10.Department of Biomedical EngineeringEindhoven University of TechnologyEindhovenThe Netherlands
  11. 11.Houston Methodist DeBakey Heart & Vascular CenterHoustonUSA
  12. 12.Department of MathematicsUniversity of HoustonHoustonUSA
  13. 13.Department of Mathematics, Center for Interdisciplinary Applied MathematicsUniversity of North Carolina at Chapel HillChapel HillUSA
  14. 14.McAllister Heart InstituteUniversity of North Carolina at Chapel Hill School of MedicineChapel HillUSA

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