Annals of Biomedical Engineering

, Volume 43, Issue 7, pp 1543–1554 | Cite as

Coupled Simulation of Hemodynamics and Vascular Growth and Remodeling in a Subject-Specific Geometry

Article

Abstract

A computational framework to couple vascular growth and remodeling (G&R) with blood flow simulation in a 3D patient-specific geometry is presented. Hyperelastic and anisotropic properties are considered for the vessel wall material and a constrained mixture model is used to represent multiple constituents in the vessel wall, which was modeled as a membrane. The coupled simulation is divided into two time scales—a longer time scale for G&R and a shorter time scale for fluid dynamics simulation. G&R is simulated to evolve the boundary of the fluid domain, and fluid simulation is in turn used to generate wall shear stress and transmural pressure data that regulates G&R. To minimize required computation cost, the fluid dynamics are only simulated when G&R causes significant vascular geometric change. For demonstration, this coupled model was used to study the influence of stress-mediated growth parameters, and blood flow mechanics, on the behavior of the vascular tissue growth in a model of the infrarenal aorta derived from medical image data.

Keywords

Aneurysm Blood flow Constrained mixture Coupled simulation Growth and remodeling 

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Copyright information

© Biomedical Engineering Society 2015

Authors and Affiliations

  1. 1.Mechanical EngineeringUniversity of CaliforniaBerkeleyUSA

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