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Annals of Biomedical Engineering

, Volume 43, Issue 8, pp 1786–1802 | Cite as

Computational Modelling of Multi-folded Balloon Delivery Systems for Coronary Artery Stenting: Insights into Patient-Specific Stent Malapposition

  • Georgios E. Ragkousis
  • Nick Curzen
  • Neil W. Bressloff
Article

Abstract

Despite the clinical effectiveness of coronary artery stenting, percutaneous coronary intervention or “stenting” is not free of complications. Stent malapposition (SM) is a common feature of “stenting” particularly in challenging anatomy, such as that characterized by long, tortuous and bifurcated segments. SM is an important risk factor for stent thrombosis and recently it has been associated with longitudinal stent deformation. SM is the result of many factors including reference diameter, vessel tapering, the deployment pressure and the eccentric anatomy of the vessel. For the purpose of the present paper, virtual multi-folded balloon models have been developed for simulated deployment in both constant and varying diameter vessels under uniform pressure. The virtual balloons have been compared to available compliance charts to ensure realistic inflation response at nominal pressures. Thereafter, patient-specific simulations of stenting have been conducted aiming to reduce SM. Different scalar indicators, which allow a more global quantitative judgement of the mechanical performance of each delivery system, have been implemented. The results indicate that at constant pressure, the proposed balloon models can increase the minimum stent lumen area and thereby significantly decrease SM.

Keywords

Coronary stents Balloon delivery systems Patient-specific model Stent malapposition Finite element analysis 

Abbreviations

PCI

Percutaneous coronary intervention

SM

Stent malapposition

ST

Stent thrombosis

DES

Drug eluting stent

FEA

Finite element analysis

RCA

Right coronary artery

LAD

Left anterior descenting

Cx

Circumflex

LM

Left main

TAC

Total average curvature

TAT

Total average torsion

VAS

Volume average stress

AASM

Area average stent malapposition

MLA

Minimum lumen area

VG

Volume gain

Notes

Acknowledgments

This work was funded by Medtronic Inc. (Minnesota, USA), the Faculty of Engineering and the Environment and the Faculty of Medicine of Southampton University. The authors would like to acknowledge the unrestricted support offered which ultimately allowed the project to be completed.

Supplementary material

10439_2014_1237_MOESM1_ESM.pdf (1001 kb)
Supplementary material 1 (pdf 1064291 kb)

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Copyright information

© Biomedical Engineering Society 2015

Authors and Affiliations

  • Georgios E. Ragkousis
    • 1
  • Nick Curzen
    • 2
    • 3
  • Neil W. Bressloff
    • 1
  1. 1.Computational Engineering & Design Group, Engineering & the EnvironmentUniversity of Southampton SouthamptonUK
  2. 2.Wessex Cardiothoracic and Vascular Care GroupUniversity Hospital Southampton, NHS Foundation TrustSouthamptonUK
  3. 3.Faculty of MedicineUniversity of SouthamptonSouthamptonUK

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