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Computational Modeling of Flow-Altering Surgeries in Basilar Aneurysms

Abstract

In cases where surgeons consider different interventional options for flow alterations in the setting of pathological basilar artery hemodynamics, a virtual model demonstrating the flow fields resulting from each of these options can assist in making clinical decisions. In this study, image-based computational fluid dynamics (CFD) models were used to simulate the flow in four basilar artery aneurysms in order to evaluate postoperative hemodynamics that would result from flow-altering interventions. Patient-specific geometries were constructed using MR angiography and velocimetry data. CFD simulations carried out for the preoperative flow conditions were compared to in vivo phase-contrast MRI measurements (4D Flow MRI) acquired prior to the interventions. The models were then modified according to the procedures considered for each patient. Numerical simulations of the flow and virtual contrast transport were carried out in each case in order to assess postoperative flow fields and estimate the likelihood of intra-aneurysmal thrombus deposition following the procedures. Postoperative imaging data, when available, were used to validate computational predictions. In two cases, where the aneurysms involved vital pontine perforator arteries branching from the basilar artery, idealized geometries of these vessels were incorporated into the CFD models. The effect of interventions on the flow through the perforators was evaluated by simulating the transport of contrast in these vessels. The computational results were in close agreement with the MR imaging data. In some cases, CFD simulations could help determine which of the surgical options was likely to reduce the flow into the aneurysm while preserving the flow through the basilar trunk. The study demonstrated that image-based computational modeling can provide guidance to clinicians by indicating possible outcome complications and indicating expected success potential for ameliorating pathological aneurysmal flow, prior to a procedure.

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Acknowledgments

We acknowledge Grant support from the NIHHL115267 (VLR).

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Correspondence to V. L. Rayz.

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Associate Editor Kent Leach oversaw the review of this article.

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Rayz, V.L., Abla, A., Boussel, L. et al. Computational Modeling of Flow-Altering Surgeries in Basilar Aneurysms. Ann Biomed Eng 43, 1210–1222 (2015). https://doi.org/10.1007/s10439-014-1170-x

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Keywords

  • Image-based computational modeling
  • Computational fluid dynamics
  • Basilar artery aneurysm
  • Magnetic resonance imaging
  • Indirect aneurysm occlusion