Annals of Biomedical Engineering

, Volume 42, Issue 7, pp 1494–1507 | Cite as

Tissue Engineering and Regenerative Repair in Wound Healing

  • Michael S. Hu
  • Zeshaan N. Maan
  • Jen-Chieh Wu
  • Robert C. Rennert
  • Wan Xing Hong
  • Tiffany S. Lai
  • Alexander T. M. Cheung
  • Graham G. Walmsley
  • Michael T. Chung
  • Adrian McArdle
  • Michael T. Longaker
  • H. Peter Lorenz


Wound healing is a highly evolved defense mechanism against infection and further injury. It is a complex process involving multiple cell types and biological pathways. Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation. In contrast, early to mid-gestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation. This early observation has led to extensive research seeking to unlock the mechanism underlying fetal scarless regenerative repair. Building upon recent advances in biomaterials and stem cell applications, tissue engineering approaches are working towards a recapitulation of this phenomenon. In this review, we describe the elements that distinguish fetal scarless and adult scarring wound healing, and discuss current trends in tissue engineering aimed at achieving scarless tissue regeneration.


Biomaterials Cell-based therapeutics Fetal wound healing Stem cells 


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Copyright information

© Biomedical Engineering Society 2014

Authors and Affiliations

  • Michael S. Hu
    • 1
    • 2
  • Zeshaan N. Maan
    • 1
  • Jen-Chieh Wu
    • 1
  • Robert C. Rennert
    • 1
  • Wan Xing Hong
    • 1
  • Tiffany S. Lai
    • 3
  • Alexander T. M. Cheung
    • 1
  • Graham G. Walmsley
    • 1
  • Michael T. Chung
    • 1
  • Adrian McArdle
    • 1
  • Michael T. Longaker
    • 1
  • H. Peter Lorenz
    • 1
  1. 1.Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic SurgeryStanford University School of MedicineStanfordUSA
  2. 2.Department of Surgery, John A. Burns School of MedicineUniversity of Hawai’iHonoluluUSA
  3. 3.Department of Obstetrics and Gynecology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA

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