Validation of Algorithms for the Estimation of Pulse Transit Time: Where do We Stand Today?
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Gaddum et al.,2 recently published in Annals of Biomedical Engineering an interesting article seeking the optimal method for the estimation of arterial pulse transit time (TT) between two arterial sites. Accurate and precise TT estimation in vivo is a critical issue, because TT is one of the two parameters (together with distance measurement) needed for the calculation of pulse wave velocity (PWV).
PWV is the hallmark of the assessment of arterial stiffness in clinical practice. To date carotid-to-femoral PWV, a measure of segmental stiffness between ascending aorta and femoral artery, is recommended as the gold standard to evaluate arterial stiffening.3 PWV is estimated by the ratio of the distance (m) travelled by a pressure, velocity or distension wave between two arterial sites to the TT. It is not possible to measure TT in vivo by direct means and hence several computational algorithms have been proposed aiming to determine the time delay between two waves.
Gaddum et al.2aimed...
KeywordsTransit Time Pulse Wave Velocity Applanation Tonometry Pulse Transit Time Arterial Site
- 3.Laurent, S., J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, and H. Struijker-Boudier. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur. Heart J. 27:2588–2605, 2006.PubMedCrossRefGoogle Scholar