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Annals of Biomedical Engineering

, Volume 42, Issue 4, pp 871–884 | Cite as

Crowd-Sourced Annotation of ECG Signals Using Contextual Information

  • Tingting Zhu
  • Alistair E. W. Johnson
  • Joachim Behar
  • Gari D. Clifford
Article

Abstract

For medical applications, the ground truth is ascertained through manual labels by clinical experts. However, significant inter-observer variability and various human biases limit accuracy. A probabilistic framework addresses these issues by comparing aggregated human and automated labels to provide a reliable ground truth, with no prior knowledge of the individual performance. As an alternative to median or mean voting strategies, novel contextual features (signal quality and physiology) were introduced to allow the Probabilistic Label Aggregator (PLA) to weight an algorithm or human based on its performance. As a proof of concept, the PLA was applied to QT interval (pro-arrhythmic indicator) estimation from the electrocardiogram using labels from 20 humans and 48 algorithms crowd-sourced from the 2006 PhysioNet/Computing in Cardiology Challenge database. For automatic annotations, the root mean square error of the PLA was 13.97 ± 0.46 ms, significantly outperforming the best Challenge entry (16.36 ms) as well as mean and median voting strategies (17.67 ± 0.56 ms and 14.44 ± 0.52 ms respectively with p < 0.05). When selecting three annotators, the PLA improved the annotation accuracy over median aggregation by 10.7% for human annotators and 14.4% for automated algorithms. The PLA could therefore provide an improved “gold standard” for medical annotation tasks even when ground truth is not available.

Keywords

Probabilistic analysis Crowd-sourcing Unsupervised learning ECG QT estimation Signal quality 

Notes

Acknowledgments

TZ and AJ acknowledge the support of the RCUK Digital Economy Programme grant number EP/G036861/1 (Oxford Centre for Doctoral Training in Healthcare Innovation). TZ also acknowledges the support of China Mobile Research Institute. JB is supported by the UK EPSRC, the Balliol French Anderson Scholarship Fund, and MindChild Medical Inc. (North Andover, MA).

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Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  • Tingting Zhu
    • 1
  • Alistair E. W. Johnson
    • 1
  • Joachim Behar
    • 1
  • Gari D. Clifford
    • 1
  1. 1.Intelligent Patient Monitoring Group, Institute of Biomedical Engineering, Department of Engineering ScienceUniversity of OxfordOxfordUK

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