Annals of Biomedical Engineering

, Volume 41, Issue 9, pp 1913–1925 | Cite as

Innovation and Translation Efforts in Wireless Medical Connectivity, Telemedicine and eMedicine: A Story from the RFID Center of Excellence at the University of Pittsburgh

  • Ervin Sejdić
  • Michael A. Rothfuss
  • Joshua R. Stachel
  • Nicholas G. Franconi
  • Kara Bocan
  • Michael R. Lovell
  • Marlin H. Mickle


Translational research has recently been rediscovered as one of the basic tenants of engineering. Although many people have numerous ideas of how to accomplish this successfully, the fundamental method is to provide an innovative and creative environment. The University of Pittsburgh has been accomplishing this goal though a variety of methodologies. The contents of this paper are exemplary of what can be achieved though the interaction of students, staff, faculty and, in one example, high school teachers. While the projects completed within the groups involved in this paper have spanned other areas, the focus of this paper is on the biomedical devices, that is, towards improving and maintaining health in a variety of areas. The spirit of the translational research is discovery, invention, intellectual property protection, and the creation of value through the spinning off of companies while providing better health care and creating jobs. All but one of these projects involve wireless radio frequency (RF) energy for delivery. The remaining device can be wirelessly connected for data collection.


Translation research University of Pittsburgh Robo-Rat Wireless deep brain stimulation Vagus nerve stimulation Electroporation device Wireless Doppler Programmable pulse oximetry Implantable RFID tags Implantable blood flow monitor 


  1. 1.
    Aarsland, D., J. Zaccai, and C. Brayne. A systematic review of prevalence studies of dementia in Parkinson’s disease. Mov. Disord. 20(10):1255–1263, 2005.PubMedCrossRefGoogle Scholar
  2. 2.
    Abell, K. M., R. S. Baker, D. E. Cowen, and J. D. Porter. Efficacy of gold weight implants in facial nerve palsy: quantitative alterations in blinking. Vision Res. 38(19):3019–3023, 1998.PubMedCrossRefGoogle Scholar
  3. 3.
    Andr, F., and L. M. Mir. DNA electrotransfer: its principles and an updated review of its therapeutic applications. Gene Ther. 11:S33–S42, 2004.CrossRefGoogle Scholar
  4. 4.
    Baroletti, S., and H. Dell’Orfano. Medication adherence in cardiovascular disease. Circulation 121(12):1455–1458, 2010.PubMedCrossRefGoogle Scholar
  5. 5.
    Berney, A., F. Vingerhoets, A. Perrin, P. Guex, J.-G. Villemure, P. R. Burkhard, C. Benkelfat, and J. Ghika. Effect on mood of subthalamic DBS for Parkinsons disease: a consecutive series of 24 patients. Neurology 59(9):1427–1429, 2002.PubMedCrossRefGoogle Scholar
  6. 6.
    Bohm, E. R., M. J. Dunbar, and R. Bourne. The Canadian joint replacement registry—what have we learned? Acta Orthop. 81(1):119–121, 2010.PubMedCrossRefGoogle Scholar
  7. 7.
    Boon, P., K. Vonck, V. DeHerdt, A. VanDycke, M. Goethals, L. Goossens, M. VanZandijcke, T. DeSmedt, I. Dewaele, R. Achten, W. Wadman, F. Dewaele, J. Caemaert, and D. VanRoost. Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia 48(8):1551–1560, 2007.PubMedCrossRefGoogle Scholar
  8. 8.
    Bowman, K. G., and M. J. Carty. Flap complications and thrombophilia: an evidence-based model and cost analysis for preoperative screening. ePlasty 11:278–289, 2011.Google Scholar
  9. 9.
    Cronin, G. W., and R. L. Steenerson. The effectiveness of neuromuscular facial retraining combined with electromyography in facial paralysis rehabilitation. Otolaryngol. Head Neck Surg. 128(4):534–538, 2003.PubMedCrossRefGoogle Scholar
  10. 10.
    Cutler, D. M., and W. Everett. Thinking outside the pillbox - medication adherence as a priority for health care reform. N. Engl. J. Med. 362(17): 1553–1555, 2010.PubMedCrossRefGoogle Scholar
  11. 11.
    Dean, D. A., D. Machado-Aranda, K. Blair-Parks, A. V. Yeldandi, and J. L. Young. Electroporation as a method for high-level nonviral gene transfer to the lung. Gene Ther. 10(18):1608–1616, 2003.PubMedCrossRefGoogle Scholar
  12. 12.
    Disa, J. J., Q. Y. Hu, and D. A. Hidalgo. Retrospective review of 400 consecutive free flap reconstructions for oncologic surgical defects. Ann. Surg. Oncol. 4(4):663–669, 1997.PubMedCrossRefGoogle Scholar
  13. 13.
    Dona, M., M. Sandri, K. Rossini, I. Dell’Aica, M. Podhorska-Okolow, and U. Carraro. Functional in vivo gene transfer into the myofibers of adult skeletal muscle. Biochem. Biophys. Res. Commun. 312(4):1132–1138, 2003.PubMedCrossRefGoogle Scholar
  14. 14.
    Farmer, K. C. Medication adherence in health care: are we utilizing what we have learned? Clin. Ther. 33(8):1081–1083, 2011.PubMedCrossRefGoogle Scholar
  15. 15.
    Fasano, A., P. Mazzone, C. Piano, D. Quaranta, F. Soleti, and A. R. Bentivoglio. GPi-DBS in Huntington’s disease: results on motor function and cognition in a 72-year-old case. Mov. Disord. 23(9):1289–1292, 2008.PubMedCrossRefGoogle Scholar
  16. 16.
    Fattori, E., N. La Monica, G. Ciliberto, and C. Toniatti. Electro-gene-transfer: a new approach for muscle gene delivery. Somat. Cell Mol. Genet. 27(1/6):75–83, 2002.PubMedCrossRefGoogle Scholar
  17. 17.
    Gantz, B. J., J. T. Rubinstein, P. Gidley, and G. G. Woodworth. Surgical management of Bell’s palsy. Laryngoscope. 109(8):1177–1188, 1999.PubMedCrossRefGoogle Scholar
  18. 18.
    Gilbard, S. M., and C. P. Daspit. Reanimation of the paretic eyelid using gold weight implantation: a new approach and prospective evaluation. Ophthal. Plast. Reconstr. Surg. 7(2):93–103, 1991.PubMedCrossRefGoogle Scholar
  19. 19.
    Goetz, C. G., W. Poewe, O. Rascol, and C. Sampaio. Evidence-based medical review update: pharmacological and surgical treatments of Parkinson’s disease: 2001 to 2004. Mov. Disord. 20(5):523–539, 2005.PubMedCrossRefGoogle Scholar
  20. 20.
    Ho, P. M., C. L. Bryson, and J. S. Rumsfeld. Medication adherence: its importance in cardiovascular outcomes. Circulation 119(23):3028–3035, 2009.PubMedCrossRefGoogle Scholar
  21. 21.
    Ishihata, H., T. Tomoe, K. Takei, T. Hirano, K. Yoshida, S. Shoji, H. Shimauchi, and H. Horiuchi. A radio frequency identification implanted in a tooth can communicate with the outside world. IEEE Trans. Inf. Technol. Biomed. 11(6):683–685, 2007.PubMedCrossRefGoogle Scholar
  22. 22.
    Jacob, D. K., S. T. Stefko, S. A. Hackworth, M. R. Lovell, and M. H. Mickle. Communication between functional and denervated muscles using radio frequency. Otolaryngol. Head Neck Surg. 134(5):862–867, 2006.PubMedCrossRefGoogle Scholar
  23. 23.
    Jain, A., B. E. Stein, R. L. Skolasky, L. C. Jones, M. W. Hungerford. Total joint arthroplasty in patients with rheumatoid arthritis: a United States experience from 1992 through 2005. J. Arthroplasty 27(6):881–888, 2005.CrossRefGoogle Scholar
  24. 24.
    Kim, J.-Y., H.-J. Lee, N.-S. Byeon, H.-C. Kim, K.-S. Ha, and C.-Y. Chung. Development and impact of radio-frequency identification-based workflow management in health promotion center: using interrupted time-series analysis. IEEE Trans. Inf. Technol. Biomed. 14(4):935–940, 2010.PubMedCrossRefGoogle Scholar
  25. 25.
    Kirksey, M., Y. LinChiu, and Y. Ma, A. Gonzalez DellaValle, L. Poultsides, P. Gerner, and S. G. Memtsoudis. Trends in in-hospital major morbidity and mortality after total joint arthroplasty: United States 1998–2008. Anesth. Analg. 115(2):321–327, 2012.PubMedCrossRefGoogle Scholar
  26. 26.
    Kline, J. A., J. Hernandez-Nino, C. D. Newgard, D. N. Cowles, R. E. Jackson, and D. Courtney. Use of pulse oximetry to predict in-hospital complications in normotensive patients with pulmonary embolism. Am. J. Med. 115(3):203–208, 2003.PubMedCrossRefGoogle Scholar
  27. 27.
    Koppel, R. I., C. M. Druschel, T. Carter, B. E. Goldberg, P. N. Mehta, R. Talwar, and F. Z. Bierman. Effectiveness of pulse oximetry screening for congenital heart disease in asymptomatic newborns. Pediatrics 111(3):451–455, 2003.PubMedCrossRefGoogle Scholar
  28. 28.
    Kumar, R., A. M. Lozano, Y. J. Kim, W. D. Hutchison, E. Sime, E. Halket, and A. E. Lang. Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson’s disease. Neurology 51(3):850–855, 1998.PubMedCrossRefGoogle Scholar
  29. 29.
    Kurtz, S., K. Ong, E. Lau, F. Mowat, and M. Halpern. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J. Bone Joint Surg. 89(4):780–785, 2007.PubMedCrossRefGoogle Scholar
  30. 30.
    Lang, A. E., and A. M. Lozano. Parkinson’s disease. N. Engl. J. Med. 339(15):1044–1053, 1998.PubMedCrossRefGoogle Scholar
  31. 31.
    Lee, S.-Y., L.-H. Wang, and Q. Fang. A low-power RFID integrated circuits for intelligent healthcare systems. IEEE Trans. Inf. Technol. Biomed. 14(6): 1387–1396, 2010.PubMedCrossRefGoogle Scholar
  32. 32.
    Limousin, P., P. Krack, P. Pollak, A. Benazzouz, C. Ardouin, D. Hoffmann, and A.-L. Benabid. Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N. Engl. J. Med. 339(16):1105–1111, 1998.PubMedCrossRefGoogle Scholar
  33. 33.
    Lin, C.-C., M.-J. Chiu, C.-C. Hsiao, R.-G. Lee, and Y.-S. Tsai. Wireless health care service system for elderly with dementia. IEEE Trans. Inf. Technol. Biomed. 10(4):696–704, 1990.CrossRefGoogle Scholar
  34. 34.
    Lin, C.-C., P.-Y. Lin, P.-K. Lu, G.-Y. Hsieh, W.-L. Lee, and R.-G. Lee. A healthcare integration system for disease assessment and safety monitoring of dementia patients. IEEE Trans. Inf. Technol. Biomed. 12(5):579–586, 2008.PubMedCrossRefGoogle Scholar
  35. 35.
    Liu, F., S. Heston, L. M. Shollenberger, B. Sun, M. H. Mickle, M. Lovell, and L. Huang. Mechanism of in vivo DNA transport into cells by electroporation: electrophoresis across the plasma membrane may not be involved. J. Gene Med. 8(3):353–361, 2006.PubMedCrossRefGoogle Scholar
  36. 36.
    Morisky, D. E., L. W. Green, and D. M. Levine. Concurrent and predictive validity of a self-reported measure of medication adherence. Med. Care 24(1):67–74, 1986.PubMedCrossRefGoogle Scholar
  37. 37.
    Neumann, E., S. Kakorin, and K. Toensing. Fundamentals of electroporative delivery of drugs and genes. Bioelectrochem. Bioenerg. 48(1):3–16, 1999.PubMedCrossRefGoogle Scholar
  38. 38.
    Novakovic, D., R. S. Patel, D. P. Goldstein, and P. J. Gullane. Salvage of failed free flaps used in head and neck reconstruction. Head Neck Oncol. 1:33, 2009.Google Scholar
  39. 39.
    Ogirala, A., M. A. Rothfuss, J. Stachel, R. Yalamanchili, M. H. Mickle, and S. Saba. Analysis of electromagnetic interference to cardiac implantable electronic devices from RFID using tissue interface circuit. In: Proceedings of the ACES Conference on Applied Computational Electromagnetics, Williamsburgh, Virginia, USA, March, 27–31, 2011.Google Scholar
  40. 40.
    Ogirala, A., J. R. Stachel, and M. H. Mickle. Electromagnetic interference of cardiac rhythmic monitoring devices to radio frequency identification: analytical analysis and mitigation methodology. IEEE Trans. Inf. Technol. Biomed. 15(6):848–853, 2011.PubMedCrossRefGoogle Scholar
  41. 41.
    Ostrem, J. L., and P. A. Starr. Treatment of dystonia with deep brain stimulation. Neurotherapeutics 5(2):320–330, 2008.PubMedCrossRefGoogle Scholar
  42. 42.
    Papel, I. ed. Facial Plastic and Reconstructive Surgery. New York, NY: Thieme Medical Publishers, 2009.Google Scholar
  43. 43.
    Paxton, E. W., M. C. S. Inacio, M. Khatod, E. J. Yue, and R. S. Namba. Kaiser permanente national total joint replacement registry: aligning operations with information technology. Clin. Orthop. Relat. Res. 468(10):2646–2663, 2010.PubMedCrossRefGoogle Scholar
  44. 44.
    Peitersen, E. Bells palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngolog. 549:4–30, 2002.Google Scholar
  45. 45.
    Pinsky, M. R., L. Brochard, and J. Mancebo. Applied Physiology in Intensive Care Medicine. Berlin: Springer, 2006.Google Scholar
  46. 46.
    Reijnders, J. S. A. M., U. Ehrt, W. E. J. Weber, D. Aarsland, and A. F. G. Leentjens. A systematic review of prevalence studies of depression in Parkinson’s disease. Mov. Disord. 23(2):183–189, 2008.PubMedCrossRefGoogle Scholar
  47. 47.
    Severinghaus, J. W., and J. Kelleher. Recent developments in pulse oximetry. Anesthesiology 76(6):1018–1038, 1992.PubMedCrossRefGoogle Scholar
  48. 48.
    Sutherland, J., and W.-J. vanden Heuvel. Towards an intelligent hospital environment: adaptive workflow in the or of the future. In: Proceedings of the 39th Annual Hawaii International Conference on System Sciences (HICSS ’06), Vol. 5, Kauai, HI, USA, January, 4–7, 2006: pp. 100b-1–10, 2006.Google Scholar
  49. 49.
    Syed, N. A., A. Delgado, F. Sandbrink, A. E. Schulman, M. Hallett, and M. K. Floeter. Blink reflex recovery in facial weakness: an electrophysiologic study of adaptive changes. Neurology 52(4):834, 1999.PubMedCrossRefGoogle Scholar
  50. 50.
    Tremper, K. K. Pulse oximetry. Chest 95(4):713–715, 1989.PubMedCrossRefGoogle Scholar
  51. 51.
    Wells, D. J. Gene therapy progress and prospects: electroporation and other physical methods. Gene Ther. 11(18):1363–1369, 2004.PubMedCrossRefGoogle Scholar
  52. 52.
    Yao, W., C.-H. Chu, and Z. Li. The use of RFID in healthcare: benefits and barriers. In: 2010 IEEE International Conference on RFID-Technology and Applications (RFID-TA), Guangzhou, China, June, 17–19, 2010, pp. 128–134.Google Scholar

Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  • Ervin Sejdić
    • 1
  • Michael A. Rothfuss
    • 1
  • Joshua R. Stachel
    • 1
  • Nicholas G. Franconi
    • 1
  • Kara Bocan
    • 1
  • Michael R. Lovell
    • 2
  • Marlin H. Mickle
    • 1
  1. 1.Department of Electrical and Computer Engineering, Swanson School of EngineringUniversity of PittsburghPittsburghUSA
  2. 2.University of Wisconsin-MilwaukeeMilwaukeeUSA

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