Annals of Biomedical Engineering

, Volume 41, Issue 12, pp 2603–2616 | Cite as

Topology of Blood Transport in the Human Left Ventricle by Novel Processing of Doppler Echocardiography

  • Sahar Hendabadi
  • Javier Bermejo
  • Yolanda Benito
  • Raquel Yotti
  • Francisco Fernández-Avilés
  • Juan C. del Álamo
  • Shawn C. Shadden
Article

Abstract

Novel processing of Doppler-echocardiography data was used to study blood transport in the left ventricle (LV) of six patients with dilated cardiomyopathy and six healthy volunteers. Bi-directional velocity field maps in the apical long axis of the LV were reconstructed from color-Doppler echocardiography. Resulting velocity field data were used to perform trajectory-based computation of Lagrangian coherent structures (LCS). LCS were shown to reveal the boundaries of blood injected and ejected from the heart over multiple beats. This enabled qualitative and quantitative assessments of blood transport patterns and residence times in the LV. Quantitative assessments of stasis in the LV are reported, as well as characterization of LV vortex formations from E-wave and A-wave filling.

Keywords

Cardiomyopathy Intracardiac blood flow Lagrangian coherent structures Velocimetry 

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Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  • Sahar Hendabadi
    • 1
  • Javier Bermejo
    • 2
    • 3
  • Yolanda Benito
    • 2
    • 3
  • Raquel Yotti
    • 2
    • 3
  • Francisco Fernández-Avilés
    • 2
    • 3
  • Juan C. del Álamo
    • 4
  • Shawn C. Shadden
    • 1
    • 5
  1. 1.Department of Mechanical, Materials and Aerospace EngineeringIllinois Institute of TechnologyChicagoUSA
  2. 2.Department of CardiologyHospital General Universitario Gregorio MarañónMadridSpain
  3. 3.Instituto de Investigación Sanitaria Gregorio MarañónMadridSpain
  4. 4.Department of Mechanical and Aerospace Engineering, Institute for Engineering in MedicineUniversity of California San DiegoLa JollaUSA
  5. 5.Department of Mechanical EngineeringUniversity of CaliforniaBerkeleyUSA

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