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Annals of Biomedical Engineering

, Volume 41, Issue 7, pp 1459–1477 | Cite as

The Role of Geometric and Biomechanical Factors in Abdominal Aortic Aneurysm Rupture Risk Assessment

  • Samarth S. Raut
  • Santanu Chandra
  • Judy Shum
  • Ender A. FinolEmail author
Article

Abstract

The current clinical management of abdominal aortic aneurysm (AAA) disease is based to a great extent on measuring the aneurysm maximum diameter to decide when timely intervention is required. Decades of clinical evidence show that aneurysm diameter is positively associated with the risk of rupture, but other parameters may also play a role in causing or predisposing the AAA to rupture. Geometric factors such as vessel tortuosity, intraluminal thrombus volume, and wall surface area are implicated in the differentiation of ruptured and unruptured AAAs. Biomechanical factors identified by means of computational modeling techniques, such as peak wall stress, have been positively correlated with rupture risk with a higher accuracy and sensitivity than maximum diameter alone. The objective of this review is to examine these factors, which are found to influence AAA disease progression, clinical management and rupture potential, as well as to highlight on-going research by our group in aneurysm modeling and rupture risk assessment.

Keywords

Aneurysm Geometric modeling Biomechanics Rupture Finite element analysis Image segmentation 

Notes

Acknowledgments

The authors would like to acknowledge research funding from NIH Grants R21EB007651, R15HL087268, and R21EB008804. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We are also thankful to Dr. Satish Muluk of the Western Pennsylvania Allegheny Health System for his insightful discussions on clinical management of vascular disease and peri-operative AAA risk factors.

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Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  • Samarth S. Raut
    • 1
    • 2
  • Santanu Chandra
    • 2
  • Judy Shum
    • 3
  • Ender A. Finol
    • 2
    Email author
  1. 1.Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghUSA
  2. 2.Department of Biomedical EngineeringThe University of Texas at San AntonioSan AntonioUSA
  3. 3.Department of Biomedical EngineeringCarnegie Mellon UniversityPittsburghUSA

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