Annals of Biomedical Engineering

, Volume 41, Issue 9, pp 1860–1868

Design, Evaluation, and Dissemination of a Plastic Syringe Clip to Improve Dosing Accuracy of Liquid Medications

  • Garrett J. Spiegel
  • Cindy Dinh
  • Amanda Gutierrez
  • Julia Lukomnik
  • Benjamin Lu
  • Kamal Shah
  • Tara Slough
  • Ping Teresa Yeh
  • Yvette Mirabal
  • Lauren Vestewig Gray
  • Stephanie Marton
  • Michelle Adler
  • Gordon E. Schutze
  • Hadley Wickham
  • Maria Oden
  • Rebecca Richards-Kortum
Article

DOI: 10.1007/s10439-013-0780-z

Cite this article as:
Spiegel, G.J., Dinh, C., Gutierrez, A. et al. Ann Biomed Eng (2013) 41: 1860. doi:10.1007/s10439-013-0780-z

Abstract

Pediatricians in Africa requested a tool to improve caregiver dosing of liquid antiretroviral medication. We developed, evaluated and disseminated a clip to control the amount of medication drawn into an oral syringe. In a laboratory, a user tested clips of different lengths, corresponding to different volumes, by drawing water into a syringe with a clip. In Texas and Malawi, 149 adults attempted to measure Pepto-Bismol™ using a syringe with a clip, a syringe without a clip, and a dosing cup, in a randomly assigned order. In the laboratory, the volume of liquid, ranging from 1 to 4.5 mL, drawn into the syringe was always within at least 5 μL of the intended dose. In Texas, 84% of doses were accurate within ±10%, vs. 63% using the syringe alone, and 21% with the dosing cup. In Malawi, 98% of doses were accurate to within ±10%, vs. 90% using the syringe alone, and 27% with the dosing cup. For target accuracy values within ±45% (±21%), a significantly higher fraction of Houston (Kamangira) participants delivered an accurate dose using the syringe with the clip than with the syringe alone (p < 0.05). The clip enables a greater proportion of users to accurately measure liquid medication.

Keywords

Dosing error Measuring devices Medication administration Medication errors Global health Low-resource settings 

Copyright information

© Biomedical Engineering Society 2013

Authors and Affiliations

  • Garrett J. Spiegel
    • 1
  • Cindy Dinh
    • 1
  • Amanda Gutierrez
    • 1
  • Julia Lukomnik
    • 1
  • Benjamin Lu
    • 1
  • Kamal Shah
    • 1
  • Tara Slough
    • 1
  • Ping Teresa Yeh
    • 1
  • Yvette Mirabal
    • 1
  • Lauren Vestewig Gray
    • 1
  • Stephanie Marton
    • 2
  • Michelle Adler
    • 2
  • Gordon E. Schutze
    • 2
  • Hadley Wickham
    • 3
  • Maria Oden
    • 1
  • Rebecca Richards-Kortum
    • 1
  1. 1.Rice 360°: Institute for Global Health TechnologiesRice UniversityHoustonUSA
  2. 2.Department of PediatricsBaylor College of MedicineHoustonUSA
  3. 3.Department of StatisticsRice UniversityHoustonUSA

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