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Annals of Biomedical Engineering

, Volume 40, Issue 10, pp 2079–2097 | Cite as

Isolation, Characterization, and Differentiation of Stem Cells for Cartilage Regeneration

  • Olivia S. Beane
  • Eric M. Darling
Article

Abstract

The goal of tissue engineering is to create a functional replacement for tissues damaged by injury or disease. In many cases, impaired tissues cannot provide viable cells, leading to the investigation of stem cells as a possible alternative. Cartilage, in particular, may benefit from the use of stem cells since the tissue has low cellularity and cannot effectively repair itself. To address this need, researchers are investigating the chondrogenic capabilities of several multipotent stem cell sources, including adult and extra-embryonic mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Comparative studies indicate that each cell type has advantages and disadvantages, and while direct comparisons are difficult to make, published data suggest some sources may be more promising for cartilage regeneration than others. In this review, we identify current approaches for isolating and chondrogenically differentiating MSCs from bone marrow, fat, synovium, muscle, and peripheral blood, as well as cells from extra-embryonic tissues, ESCs, and iPSCs. Additionally, we assess chondrogenic induction with growth factors, identifying standard cocktails used for each stem cell type. Cell-only (pellet) and scaffold-based studies are also included, as is a discussion of in vivo results.

Keywords

Regenerative medicine Cell-based therapies Tissue engineering Chondrogenesis 

Notes

Acknowledgments

This work was supported in part by National Institutes of Health grant AR054673.

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© Biomedical Engineering Society 2012

Authors and Affiliations

  1. 1.Center for Biomedical EngineeringBrown UniversityProvidenceUSA
  2. 2.Department of Molecular Pharmacology, Physiology and BiotechnologyBrown UniversityProvidenceUSA
  3. 3.Department of OrthopaedicsBrown UniversityProvidenceUSA
  4. 4.School of EngineeringBrown UniversityProvidenceUSA

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