Annals of Biomedical Engineering

, Volume 40, Issue 6, pp 1339–1355 | Cite as

Patterning Methods for Polymers in Cell and Tissue Engineering

  • Hong Nam Kim
  • Do-Hyun Kang
  • Min Sung Kim
  • Alex Jiao
  • Deok-Ho Kim
  • Kahp-Yang Suh
Article

Abstract

Polymers provide a versatile platform for mimicking various aspects of physiological extracellular matrix properties such as chemical composition, rigidity, and topography for use in cell and tissue engineering applications. In this review, we provide a brief overview of patterning methods of various polymers with a particular focus on biocompatibility and processability. The materials highlighted here are widely used polymers including thermally curable polydimethyl siloxane, ultraviolet-curable polyurethane acrylate and polyethylene glycol, thermo-sensitive poly(N-isopropylacrylamide) and thermoplastic and conductive polymers. We also discuss how micro- and nanofabricated polymeric substrates of tunable elastic modulus can be used to engineer cell and tissue structure and function. Such synergistic effect of topography and rigidity of polymers may be able to contribute to constructing more physiologically relevant microenvironment.

Keywords

Patterning Biocompatible polymers Topography Rigidity Cell–biomaterial interface 

Abbreviations

Cells and related terms

ECM

extracellular matrix

MSCs

mesenchymal stem cells

hMSCs

human mesenchymal stem cells

hESCs

human embryonic stem cells

HPTFs

human patellar tendon fibroblasts

PBS

phosphate buffered saline

OPN

osteopontin

OCN

osteocalcin

Polymers

PDMS

polydimethyl siloxane

LDPE

low-density polyethylene

FEP

fluorinated ethylene propylene

PET

polyethylene terephthalate

PC

polycarbonate

PU

polyurethane

PUA

polyurethane acrylate

NOA

Norland Optical Adhesive

PEG

polyethylene glycol

PEG-DMA

polyethylene glycol dimethacrylate

PEG-DA

polyethylene glycol diacrylate

PGMEA

propylene glycol monomethyl ether acetate

pNIPAM

poly(N-isopropylacrylamide)

LCST

lower critical solution temperature

PMMA

poly(methyl methacrylate)

PS

polystyrene

PLGA

poly(lactic-co-glycolic acid)

PGA

polyglycolic acid

PLA

polylactide

PCL

polycaprolactone

PANi

polyaniline

PPy

polypyrrole

PEDOT

poly(3,4-ehtylenedioxythiophene)

PTS

paratoluenesulfonate

HA

hyaluronic acid

Lithography

UV

ultraviolet

NIL

nanoimprint lithography

RM

replica molding

SoMo

soft molding

CFL

capillary force lithography

BCL

block copolymer lithography

Others

NHLBI

National Heart, Lung and Blood Institute

FDA

Food and Drug Administration

MSDS

Material Safety Data Sheets

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Copyright information

© Biomedical Engineering Society 2012

Authors and Affiliations

  • Hong Nam Kim
    • 1
  • Do-Hyun Kang
    • 1
  • Min Sung Kim
    • 1
  • Alex Jiao
    • 2
  • Deok-Ho Kim
    • 2
  • Kahp-Yang Suh
    • 1
  1. 1.School of Mechanical and Aerospace EngineeringSeoul National UniversitySeoulKorea
  2. 2.Department of BioengineeringUniversity of WashingtonSeattleUSA

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