Annals of Biomedical Engineering

, Volume 40, Issue 5, pp 1028–1038 | Cite as

Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT

  • Damian Craiem
  • Gilles Chironi
  • Alban Redheuil
  • Mariano Casciaro
  • Elie Mousseaux
  • Alain Simon
  • Ricardo L. Armentano
Article

Abstract

An increasing number of intermediate risk asymptomatic subjects benefit from measures of atherosclerosis burden like coronary artery calcification studies with non-contrast heart computed tomography (CT). However, additional information can be derived from these studies, looking beyond the coronary arteries and without exposing the patients to further radiation. We report a semi-automatic method that objectively assesses ascending, arch and descending aorta dimension and shape from non-contrast CT datasets to investigate the effect of aging on thoracic aorta geometry. First, the segmentation process identifies the vessel centerline coordinates following a toroidal path for the curvilinear portion and axial planes for descending aorta. Then, reconstructing oblique planes orthogonal to the centerline direction, it iteratively fits circles inside the vessel cross-section. Finally, regional thoracic aorta dimensions (diameter, volume and length) and shape (vessel curvature and tortuosity) are calculated. A population of 200 normotensive men was recruited. Length, mean diameter and volume differed by 1.2 cm, 0.13 cm and 21 cm3 per decade of life, respectively. Aortic shape uncoiled with aging, reducing its tortuosity and increasing its radius of curvature. The arch was the most affected segment. In conclusion, non-contrast cardiac CT imaging can be successfully employed to assess thoracic aorta 3D morphometry.

Keywords

Aging Aortic arch uncoiling Aorta 3D reconstruction Aorta volume Aorta tortuosity 

Notes

Acknowledgments

This work was supported by the project PIP number 112-200901-00734 (CONICET) and the Houssay post-doctoral program (CONICET).

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Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Damian Craiem
    • 1
    • 2
  • Gilles Chironi
    • 3
    • 4
    • 5
  • Alban Redheuil
    • 4
    • 6
    • 7
  • Mariano Casciaro
    • 1
    • 2
  • Elie Mousseaux
    • 4
    • 6
    • 7
  • Alain Simon
    • 3
    • 4
    • 5
  • Ricardo L. Armentano
    • 1
  1. 1.Favaloro UniversityBuenos AiresArgentina
  2. 2.CONICETBuenos AiresArgentina
  3. 3.Centre de Médecine Préventive Cardiovasculaire, Hôpital Européen Georges Pompidou, APHPParisFrance
  4. 4.Faculté de Médecine, Université Paris DescartesParisFrance
  5. 5.Centre de Recherche Cardiovasculaire de l’HEGP (INSERM U970)ParisFrance
  6. 6.Département de Radiologie CardiovasculaireHôpital Européen Georges Pompidou, APHPParisFrance
  7. 7.Unité INSERM 678ParisFrance

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