Annals of Biomedical Engineering

, Volume 40, Issue 5, pp 1131–1141 | Cite as

Clinical Knowledge-Based Inference Model for Early Detection of Acute Lung Injury

  • Nicolas W. Chbat
  • Weiwei Chu
  • Monisha Ghosh
  • Guangxi Li
  • Man Li
  • Caitlyn M. Chiofolo
  • Srinivasan Vairavan
  • Vitaly Herasevich
  • Ognjen Gajic
Article

Abstract

Acute lung injury (ALI) is a devastating complication of acute illness and one of the leading causes of multiple organ failure and mortality in the intensive care unit (ICU). The detection of this syndrome is limited due to the complexity of the disease, insufficient understanding of its development and progression, and the large amount of risk factors and modifiers. In this preliminary study, we present a novel mathematical model for ALI detection. It is constructed based on clinical and research knowledge using three complementary techniques: rule-based fuzzy inference systems, Bayesian networks, and finite state machines. The model is developed in Matlab®’s Simulink environment and takes as input pre-ICU and ICU data feeds of critically ill patients. Results of the simulation model were validated against actual patient data from an epidemiologic study. By appropriately combining all three techniques the performance attained is in the range of 71.7–92.6% sensitivity and 60.3–78.4% specificity.

Keywords

Acute lung injury (ALI) Fuzzy inference system (FIS) Bayesian network (BN) Finite state machine (FSM) Intensive care unit (ICU) Clinical decision support (CDS) 

Notes

Acknowledgments

This work was partially supported by the NIH Grant RC1 LM10468Z-01.

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Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Nicolas W. Chbat
    • 1
  • Weiwei Chu
    • 1
  • Monisha Ghosh
    • 1
  • Guangxi Li
    • 2
  • Man Li
    • 2
  • Caitlyn M. Chiofolo
    • 1
  • Srinivasan Vairavan
    • 1
  • Vitaly Herasevich
    • 2
  • Ognjen Gajic
    • 2
  1. 1.Department of Controls, Communication and Healthcare InformaticsPhilips Research North AmericaBriarcliff ManorUSA
  2. 2.Mayo ClinicRochesterUSA

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