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Annals of Biomedical Engineering

, Volume 40, Issue 6, pp 1211–1227 | Cite as

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

  • Christopher Moraes
  • Geeta Mehta
  • Sasha Cai Lesher-Perez
  • Shuichi Takayama
Article

Abstract

Advances in microengineering technologies have enabled a variety of insights into biomedical sciences that would not have been possible with conventional techniques. Engineering microenvironments that simulate in vivo organ systems may provide critical insight into the cellular basis for pathophysiologies, development, and homeostasis in various organs, while curtailing the high experimental costs and complexities associated with in vivo studies. In this article, we aim to survey recent attempts to extend tissue-engineered platforms toward simulating organ structure and function, and discuss the various approaches and technologies utilized in these systems. We specifically focus on microtechnologies that exploit phenomena associated with compartmentalization to create model culture systems that better represent the in vivo organ microenvironment.

Keywords

Organ Compartment Microtechnology Microengineering Microenvironment Barrier 

Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Christopher Moraes
    • 1
  • Geeta Mehta
    • 1
  • Sasha Cai Lesher-Perez
    • 1
  • Shuichi Takayama
    • 1
    • 2
    • 3
  1. 1.Department of Biomedical EngineeringUniversity of MichiganAnn ArborUSA
  2. 2.Department of Macromolecular Science and EngineeringUniversity of MichiganAnn ArborUSA
  3. 3.Division of Nano-Bio and Chemical Engineering WCU ProjectUNISTUlsanRepublic of Korea

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