Annals of Biomedical Engineering

, Volume 40, Issue 6, pp 1301–1315 | Cite as

Engineering Approaches Toward Deconstructing and Controlling the Stem Cell Environment

  • Faramarz Edalat
  • Hojae Bae
  • Sam Manoucheri
  • Jae Min Cha
  • Ali Khademhosseini


Stem cell-based therapeutics have become a vital component in tissue engineering and regenerative medicine. The microenvironment within which stem cells reside, i.e., the niche, plays a crucial role in regulating stem cell self-renewal and differentiation. However, current biological techniques lack the means to recapitulate the complexity of this microenvironment. Nano- and microengineered materials offer innovative methods to (1) deconstruct the stem cell niche to understand the effects of individual elements; (2) construct complex tissue-like structures resembling the niche to better predict and control cellular processes; and (3) transplant stem cells or activate endogenous stem cell populations for regeneration of aged or diseased tissues. In this article, we highlight some of the latest advances in this field and discuss future applications and directions of the use of nano- and microtechnologies for stem cell engineering.


Biomaterials Nano- and microfabrication High-throughput Microfluidics Regenerative medicine 


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Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Faramarz Edalat
    • 1
    • 2
  • Hojae Bae
    • 1
    • 2
  • Sam Manoucheri
    • 1
    • 2
  • Jae Min Cha
    • 1
    • 2
  • Ali Khademhosseini
    • 1
    • 2
    • 3
  1. 1.Center for Biomedical Engineering, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolCambridgeUSA
  2. 2.Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Wyss Institute for Biologically Inspired EngineeringHarvard UniversityBostonUSA

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