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Annals of Biomedical Engineering

, Volume 40, Issue 2, pp 474–485 | Cite as

Measuring Tissue Properties and Monitoring Therapeutic Responses Using Acousto-Optic Imaging

  • Todd W. MurrayEmail author
  • Puxiang Lai
  • Ronald A. Roy
Article

Abstract

Acousto-optic imaging is a hybrid imaging technique that exploits the interaction between light and sound to image optical contrast at depth in optically turbid media with the high spatial resolution of ultrasound. Quantitative measurement of optical properties using this technique is confounded by multiple parameters that influence the detected acousto-optic signal. In this article, we describe the origin of the acousto-optic response and review techniques that have been proposed to relate this response to the optical properties of turbid media. We present an overview of two acousto-optic sensing approaches. In the first, we demonstrate that the local transport mean free path within turbid media can be obtained by varying the pressure of the ultrasound field and processing the resulting acousto-optic signals. In the second, we demonstrate that the acousto-optic response elicited by a high-intensity ultrasound field during thermal therapy can be used to monitor the onset of lesion formation, ascertain lesion volume, and provide real-time control of exposure duration.

Keywords

Ultrasound Optical imaging Ultrasound-modulated optical tomography Acousto-optic imaging Photorefractive crystal Turbid media Tissue optics High-intensity-focused ultrasound Thermal therapy 

Notes

Acknowledgments

The authors would like to acknowledge the generous financial support of the Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems under National Science Foundation Award No. EEC-9986821.

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Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringUniversity of Colorado at BoulderBoulderUSA
  2. 2.Department of Biomedical EngineeringWashington University in St. LouisSt. LouisUSA
  3. 3.Department of Mechanical EngineeringBoston UniversityBostonUSA

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