A Relation Between Near-Wall Particle-Hemodynamics and Onset of Thrombus Formation in Abdominal Aortic Aneurysms
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A novel computational particle-hemodynamics analysis of key criteria for the onset of an intraluminal thrombus (ILT) in a patient-specific abdominal aortic aneurysm (AAA) is presented. The focus is on enhanced platelet and white blood cell residence times as well as their elevated surface-shear loads in near-wall regions of the AAA sac. The generalized results support the hypothesis that a patient’s AAA geometry and associated particle-hemodynamics have the potential to entrap activated blood particles, which will play a role in the onset of ILT. Although the ILT history of only a single patient was considered, the modeling and simulation methodology provided allow for the development of an efficient computational tool to predict the onset of ILT formation in complex patient-specific cases.
KeywordsPatient-specific AAA Computational analysis ILT onset criteria
The authors would like to thank Dr. Satish Muluk and the Department of Radiology at Allegheny General Hospital for supplying the CT images used in our study, as well as Ms Julie Ng for assisting in the segmentation/surface meshing of the AAA models and Ms Emily Childress for assisting in the finalization of the manuscript. We also acknowledge research funding from the National Heart, Lung, and Blood Institute (R15HL087268) and Carnegie Mellon University’s Biomedical Engineering Department. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health. The authors also acknowledge the use of ANSYS® Academic Research, Release 12.1 (ANSYS Inc., Canonsburg, PA) for all computational fluid-particle simulations.
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