Annals of Biomedical Engineering

, Volume 38, Issue 6, pp 2056–2067 | Cite as

Current Application of Micro/Nano-Interfaces to Stimulate and Analyze Cellular Responses

  • Yoon-Kyoung Cho
  • Heungjoo Shin
  • Sung Kuk Lee
  • Taesung Kim
Article

Abstract

Microfabrication technologies have a high potential for novel approaches to access living cells at a cellular or even at a molecular level. In the course of reviewing and discussing the current application of microinterface systems including nanointerfaces to stimulate and analyze cellular responses with subcellular resolution, this article focuses on interfaces based on microfluidics, nanoparticles, and scanning electrochemical microscopy (SECM). Micro/nanointerface systems provide a novel, attractive means for cell study because they are capable of regulating and monitoring cellular signals simultaneously and repeatedly, leading us to an enhanced understanding and interpretation of cellular responses. Therefore, it is hoped that the integrated micro/nanointerfaces presented in this review will contribute to future developments of cell biology and facilitate advanced biomedical applications.

Keywords

Micro/nanointerfaces Microfabrication Microfluidics Nanoparticles Scanning electrochemical microscopy Interfacing biology 

Notes

Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) (2009-0076534), and WCU (World Class University) program through the NRF of Korea funded by the MEST (R32-2008-000-20054-0).

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Copyright information

© Biomedical Engineering Society 2010

Authors and Affiliations

  • Yoon-Kyoung Cho
    • 1
    • 2
  • Heungjoo Shin
    • 1
    • 2
  • Sung Kuk Lee
    • 1
    • 3
  • Taesung Kim
    • 1
    • 2
  1. 1.School of Nano-Biotechnology and Chemical EngineeringUlsan National Institute of Science and Technology (UNIST)UlsanKorea
  2. 2.School of Mechanical and Advanced Materials EngineeringUlsan National Institute of Science and Technology (UNIST)UlsanKorea
  3. 3.School of Energy EngineeringUlsan National Institute of Science and Technology (UNIST)UlsanKorea

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