Annals of Biomedical Engineering

, Volume 38, Issue 3, pp 1188–1203

Image-Based Modeling of Blood Flow and Vessel Wall Dynamics: Applications, Methods and Future Directions

Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28–30, 2008 Pasadena, California
Position Paper

Abstract

The objective of our session at the 2008 International Bio-Fluid Symposium and Workshop was to review the state-of-the-art in image-based modeling of blood flow, and identify future directions. Here we summarize progress in the field of image-based modeling of blood flow and vessel wall dynamics from mid-2005 to early 2009. We first describe the tremendous progress made in the application of image-based modeling techniques to elucidate the role of hemodynamics in vascular pathophysiology, plan treatments for congenital and acquired diseases in individual patients, and design and evaluate endovascular devices. We then review the advances that have been made in improving the methodology for modeling blood flow and vessel wall dynamics in image-based models, and consider issues related to extracting hemodynamic parameters and verification and validation. Finally, the strengths and weaknesses of current work in image-based modeling and the opportunities and threats to the field are described. We believe that with a doubling of our efforts toward the clinical application of image-based modeling tools, the next few years could surpass the tremendous gains made in the last few.

Keywords

Image-based modeling Patient-specific Hemodynamics Atherosclerosis Aneurysms Surgical planning 

Abbreviations

AAA

Abdominal aortic aneurysms

ALE

Arbitrary Lagrangian–Eulerian

CFD

Computational fluid dynamics

CT

Computed tomography

IMT

Intima-media thickness

IUVS

Invasive intravascular ultrasound

MRA

Magnetic resonance angiograms

MRI

Magnetic resonance imaging

PC-MRI

Phase contrast magnetic resonance imaging

US

Ultrasound

WSS

Wall shear stress

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© Biomedical Engineering Society 2010

Authors and Affiliations

  1. 1.Departments of Bioengineering and SurgeryStanford UniversityStanfordUSA
  2. 2.Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoCanada

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