Annals of Biomedical Engineering

, Volume 38, Issue 9, pp 3022–3030 | Cite as

A Model of Slow Wave Propagation and Entrainment Along the Stomach

  • Martin L. Buist
  • Alberto Corrias
  • Yong Cheng Poh
Article

Abstract

Interstitial cells of Cajal (ICC) isolated from different regions of the stomach generate spontaneous electrical slow wave activity at different frequencies, with cells from the proximal stomach pacing faster than their distal counterparts. However, in vivo there exists a uniform pacing frequency; slow waves propagate aborally from the proximal stomach and subsequently entrain distal tissues. Significant resting membrane potential (RMP) gradients also exist within the stomach whereby membrane polarization generally increases from the fundus to the antrum. Both of these factors play a major role in the macroscopic electrical behavior of the stomach and as such, any tissue or organ level model of gastric electrophysiology should ensure that these phenomena are properly described. This study details a dual-cable model of gastric electrical activity that incorporates biophysically detailed single-cell models of the two predominant cell types, the ICC and smooth muscle cells. Mechanisms for the entrainment of the intrinsic pacing frequency gradient and for the establishment of the RMP gradient are presented. The resulting construct is able to reproduce experimentally recorded slow wave activity and provides a platform on which our understanding of gastric electrical activity can advance.

Keywords

Smooth muscle cell Interstitial cell of Cajal Electrophysiology Resting membrane potential Carbon monoxide 

Abbreviations

RMP

Resting membrane potential

ICC

Interstitial cells of Cajal

SMC

Smooth muscle cell

ICC-MY

ICC from the myenteric plexus

ICC–IM

Intramuscular ICC

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Copyright information

© Biomedical Engineering Society 2010

Authors and Affiliations

  • Martin L. Buist
    • 1
  • Alberto Corrias
    • 1
  • Yong Cheng Poh
    • 1
  1. 1.Division of BioengineeringNational University of SingaporeSingaporeSingapore

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