Annals of Biomedical Engineering

, Volume 38, Issue 8, pp 2532–2541 | Cite as

A Multilead Scheme Based on Periodic Component Analysis for T-Wave Alternans Analysis in the ECG

  • Violeta Monasterio
  • Gari D. Clifford
  • Pablo Laguna
  • Juan Pablo Martínez


T-wave alternans (TWA) is a cardiac phenomenon that appears in the electrocardiogram (ECG) and is associated with the mechanisms leading to sudden cardiac death (SCD). In this study, we propose the use of a multilead TWA analysis scheme that combines the Laplacian likelihood ratio (LLR) method and periodic component analysis (πCA), an eigenvalue decomposition technique whose aim is to extract the most periodic sources of the signal. The proposed scheme is evaluated in different scenarios—from synthetic signals to stress test ECGs—and is compared to other reported schemes based on the LLR method. Results demonstrate that the πCA-based scheme provides a superior ability to detect TWA than previously reported schemes, and has the potential to improve the prognostic value of testing for TWA.


Electrocardiogram T-wave alternans Multilead analysis Periodic component analysis 



This work was supported by CIBER de Bioingeniería, Biomateriales y Nanomedicina through Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional, by Project TEC-2007-68076-C02-02 from CICYT, and by Grupo Consolidado GTC from DGA (Spain).


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Copyright information

© Biomedical Engineering Society 2010

Authors and Affiliations

  • Violeta Monasterio
    • 1
    • 2
  • Gari D. Clifford
    • 3
  • Pablo Laguna
    • 1
    • 2
  • Juan Pablo Martínez
    • 1
    • 2
  1. 1.CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)ZaragozaSpain
  2. 2.Communications Technology Group, Aragon Institute of Engineering ResearchUniversidad de ZaragozaZaragozaSpain
  3. 3.Department of Engineering Science, Institute of Biomedical EngineeringUniversity of OxfordOxfordUK

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