Annals of Biomedical Engineering

, Volume 38, Issue 8, pp 2606–2620 | Cite as

MR Image-Based Geometric and Hemodynamic Investigation of the Right Coronary Artery with Dynamic Vessel Motion

  • Ryo ToriiEmail author
  • Jennifer Keegan
  • Nigel B. Wood
  • Andrew W. Dowsey
  • Alun D. Hughes
  • Guang-Zhong Yang
  • David N. Firmin
  • Simon A. McG. Thom
  • X. Yun Xu


The aim of this study was to develop a fully subject-specific model of the right coronary artery (RCA), including dynamic vessel motion, for computational analysis to assess the effects of cardiac-induced motion on hemodynamics and resulting wall shear stress (WSS). Vascular geometries were acquired in the right coronary artery (RCA) of a healthy volunteer using a navigator-gated interleaved spiral sequence at 14 time points during the cardiac cycle. A high temporal resolution velocity waveform was also acquired in the proximal region. Cardiac-induced dynamic vessel motion was calculated by interpolating the geometries with an active contour model and a computational fluid dynamic (CFD) simulation with fully subject-specific information was carried out using this model. The results showed the expected variation of vessel radius and curvature throughout the cardiac cycle, and also revealed that dynamic motion of the right coronary artery consequent to cardiac motion had significant effects on instantaneous WSS and oscillatory shear index. Subject-specific MRI-based CFD is feasible and, if scan duration could be shortened, this method may have potential as a non-invasive tool to investigate the physiological and pathological role of hemodynamics in human coronary arteries.


Coronary artery Magnetic resonance imaging Dynamic vessel motion Computational fluid dynamics 



This work was supported by the British Heart Foundation (PG/04/078) and The Foundation for Circulatory Health (ICCH/07/5015), and the first author is currently supported by the Magdi Yacoub Institute. This project was supported by the NIHR Cardiovascular Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London. The authors are also grateful for support from the NIHR Biomedical Research Centre Funding Scheme awarded to Imperial College Healthcare NHS Trust.


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Copyright information

© Biomedical Engineering Society 2010

Authors and Affiliations

  • Ryo Torii
    • 1
    Email author
  • Jennifer Keegan
    • 2
  • Nigel B. Wood
    • 1
  • Andrew W. Dowsey
    • 3
  • Alun D. Hughes
    • 4
  • Guang-Zhong Yang
    • 3
  • David N. Firmin
    • 2
  • Simon A. McG. Thom
    • 4
  • X. Yun Xu
    • 1
  1. 1.Department of Chemical EngineeringImperial College LondonLondonUK
  2. 2.Cardiovascular MR unitRoyal Brompton HospitalLondonUK
  3. 3.Royal Society/Wolfson Medical Image Computing LaboratoryImperial College LondonLondonUK
  4. 4.International Centre for Circulatory HealthImperial College London & Imperial College Healthcare NHS TrustLondonUK

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