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Annals of Biomedical Engineering

, Volume 37, Issue 7, pp 1310–1321 | Cite as

In Vitro, Time-Resolved PIV Comparison of the Effect of Stent Design on Wall Shear Stress

  • John Charonko
  • Satyaprakash Karri
  • Jaime Schmieg
  • Santosh Prabhu
  • Pavlos VlachosEmail author
Article

Abstract

The effect of stent design on wall shear stress (WSS) and oscillatory shear index (OSI) was studied in vitro using time-resolved digital particle image velocimetry (DPIV). Four drug-eluting stents [XIENCE V® (Abbott Vascular), TAXUS® Liberté® (Boston Scientific), Endeavor® (Medtronic), and Cypher® (J&J Cordis)] and a bare-metal stent [VISION® (Abbott Vascular)] were implanted into compliant vessel models, and the flow was measured in physiologically accurate coronary conditions featuring reversal and realistic offsets between pressure and flowrate. DPIV measurements were made at three locations under two different flow rates (resting: Re = 160, f = 70 bpm and exercise: Re = 300, f = 120 bpm). It was observed that design substantially affected the WSS experienced at the vessel walls. Averaged values between struts ranged from 2.05 dynes/cm2 (Cypher®) to 8.52 dynes/cm2 (XIENCE V®) in resting conditions, and from 3.72 dynes/cm2 (Cypher®) to 14.66 dynes/cm2 (VISION®) for the exercise state. Within the stent, the WSS dropped and the OSI increased immediately distal to each strut. In addition, an inverse correlation between average WSS and OSI existed. Comparisons with recently published results from animal studies show strong correlation between the measured WSS and observed endothelial cell coverage. These results suggest the importance of stent design on the WSS experienced by endothelial cells in coronary arteries.

Keywords

Coronary arteries Blood flow Phase offset Oscillatory shear index Drug-eluting stent Bare metal stent Endothelial cells 

Notes

Acknowledgments

Abbott Vascular provided partial support for this research. This material is also based upon work supported by the National Science Foundation under CAREER award #0547434.

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Copyright information

© Biomedical Engineering Society 2009

Authors and Affiliations

  • John Charonko
    • 1
  • Satyaprakash Karri
    • 1
  • Jaime Schmieg
    • 1
  • Santosh Prabhu
    • 2
  • Pavlos Vlachos
    • 1
    Email author
  1. 1.Virginia TechBlacksburgUSA
  2. 2.Abbott VascularSanta ClaraUSA

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