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Annals of Biomedical Engineering

, Volume 36, Issue 2, pp 262–275 | Cite as

Dynamic Simulation of Bioprosthetic Heart Valves Using a Stress Resultant Shell Model

  • Hyunggun Kim
  • Jia Lu
  • Michael S. Sacks
  • Krishnan B. ChandranEmail author
Article

Abstract

It is a widely accepted axiom that localized concentration of mechanical stress and large flexural deformation is closely related to the calcification and tissue degeneration in bioprosthetic heart valves (BHV). In order to investigate the complex BHV deformations and stress distributions throughout the cardiac cycle, it is necessary to perform an accurate dynamic analysis with a morphologically and physiologically realistic material specification for the leaflets. We have developed a stress resultant shell model for BHV leaflets incorporating a Fung-elastic constitutive model for in-plane and bending responses separately. Validation studies were performed by comparing the finite element predicted displacement and strain measures with the experimentally measured data under physiological pressure loads. Computed regions of stress concentration and large flexural deformation during the opening and closing phases of the cardiac cycle correlated with previously reported regions of calcification and/or mechanical damage on BHV leaflets. It is expected that the developed experimental and computational methodology will aid in the understanding of the complex dynamic behavior of native and bioprosthetic valves and in the development of tissue engineered valve substitutes.

Keywords

Heart valve Bioprosthetic heart valve Finite element Shell Constitutive model Dynamic analysis Cardiovascular biomechanics Soft tissue modeling Calcification Heart valve failure Heart valve disease 

Notes

Acknowledgments

The partial support of this work by an USPHS grant from the National Heart, Lung, and Blood Institute (NIH: HL-071814) and the Iowa Department of Economic Development are gratefully acknowledged.

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Copyright information

© Biomedical Engineering Society 2007

Authors and Affiliations

  • Hyunggun Kim
    • 1
    • 2
  • Jia Lu
    • 3
    • 4
  • Michael S. Sacks
    • 5
  • Krishnan B. Chandran
    • 1
    • 3
    • 6
    Email author
  1. 1.Department of Biomedical Engineering, College of EngineeringUniversity of IowaIowa CityUSA
  2. 2.Department of Internal Medicine, Division of CardiologyThe University of Texas Health Science Center at HoustonHoustonUSA
  3. 3.Department of Mechanical and Industrial EngineeringUniversity of IowaIowa CityUSA
  4. 4.Center for Computer-Aided DesignUniversity of IowaIowa CityUSA
  5. 5.Department of Bioengineering, Engineered Tissue Mechanics LaboratoryUniversity of PittsburghPittsburghUSA
  6. 6.IIHR-Hydroscience and EngineeringIowa CityUSA

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